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Magnetic Resonance Imaging01:24

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Magnetic resonance imaging (MRI) is a noninvasive medical imaging technique based on a phenomenon of nuclear physics discovered in the 1930s, in which matter exposed to magnetic fields and radio waves was found to emit radio signals. In 1970, a physician and researcher named Raymond Damadian noticed that malignant (cancerous) tissue gave off different signals than normal body tissue. He applied for a patent for the first MRI scanning device in clinical use by the early 1980s. The early MRI...
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Quantitative Magnetic Resonance Imaging of Skeletal Muscle Disease
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Resolution enhanced T1-insensitive steady-state imaging.

Jamal J Derakhshan1, Sherif G Nour, Jeffrey L Sunshine

  • 1Department of Biomedical Engineering, Case Western Reserve University, Cleveland, Ohio, USA.

Magnetic Resonance in Medicine
|December 2, 2011
PubMed
Summary
This summary is machine-generated.

Resolution enhanced T(1)-insensitive steady-state imaging (RE-TOSSI) offers rapid T(2)-weighted MRI with high spatial resolution. This new sequence significantly improves image quality and acquisition speed for various applications.

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Area of Science:

  • Magnetic Resonance Imaging (MRI)
  • Medical Imaging Physics

Background:

  • T(1)-insensitive steady-state imaging (TOSSI) provides T(2) contrast using specific inversion pulses.
  • Adiabatic inversion pulses in TOSSI are energy and time-intensive, limiting acquisition speed.

Purpose of the Study:

  • To introduce and evaluate a novel MRI pulse sequence, RE-TOSSI.
  • To improve spatial resolution and reduce acquisition time for T(2)-weighted imaging.

Main Methods:

  • Developed RE-TOSSI by removing adiabatic inversion pulses from TOSSI after k-space center acquisition.
  • Utilized magnetization evolution simulations to analyze contrast and point spread function.
  • Conducted phantom experiments to compare RE-TOSSI with TOSSI, balanced SSFP, HASTE, and turbo spin echo.

Main Results:

  • RE-TOSSI demonstrated reduced point spread function widening by up to a factor of 4.
  • Phantom and in-vivo (abdomen, brain) imaging showed similar T(2) contrast with improved spatial resolution compared to TOSSI.
  • RE-TOSSI achieved high spatial resolution T(2)-weighted images in 1 second or less.

Conclusions:

  • RE-TOSSI is a viable technique for rapid, high-resolution T(2)-weighted MRI.
  • The sequence offers significant advantages in speed and spatial detail over existing methods.
  • RE-TOSSI holds promise for clinical applications requiring fast, detailed T(2) imaging.