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Identification of the novel allele HLA-A*33:22 by sequence-based typing in a Chinese individual

J-H Xie1, L-N Yan, S-Y Li

  • 1Tissue Typing Lab of Tianjin Blood Center, Tianjin, China.

Tissue Antigens
|July 19, 2012
PubMed

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A single nucleotide polymorphism or SNP is a single nucleotide variation at a specific genomic position in a large population. It is the most prevalent type of sequence variation found in the human genome. Point mutations that occur in more than 1% of the population qualify as SNPs. These are present once every 1000 nucleotides on an average in the human genome. Replacement of a purine with another purine (A/G) or a pyrimidine with another pyrimidine (C/T) is known as a transition. In contrast,...