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In vivo Structural Assessments of Ocular Disease in Rodent Models using Optical Coherence Tomography
Published on: July 24, 2020
Choroidal thickness in unilateral advanced glaucoma.
Jean-Claude Mwanza1, Fouad E Sayyad, Donald L Budenz
1Bascom Palmer Eye Institute, University of Miami Miller School of Medicine, Miami, Florida, USA. jean-claude_mwanza@med.unc.edu
Investigative Ophthalmology & Visual Science
|September 8, 2012
Summary
Advanced glaucoma does not significantly alter choroidal thickness compared to fellow eyes. Choroidal thickness is not a reliable indicator for glaucoma presence or absence.
Area of Science:
- Ophthalmology
- Glaucoma Research
- Optical Coherence Tomography
Background:
- Glaucoma is a leading cause of irreversible blindness.
- Choroidal thickness is a potential biomarker in glaucoma, but its role in advanced stages is unclear.
Purpose of the Study:
- To compare choroidal thickness in eyes with advanced glaucoma versus fellow eyes with no or mild glaucoma.
Main Methods:
- Enhanced depth imaging optical coherence tomography (OCT) was used for macular scanning.
- Choroidal thickness was measured in advanced glaucoma eyes and fellow eyes.
- Analyses adjusted for axial length and intraocular pressure.
Main Results:
- No significant differences in choroidal thickness were found between advanced glaucoma eyes and fellow eyes.
- Aging and increased axial length were associated with thinner choroids.
- Visual field status did not correlate with choroidal thickness.
Conclusions:
- Choroidal thickness does not significantly change in advanced open-angle glaucoma.
- Choroidal thickness is not a definitive indicator of glaucoma presence or absence.
- A lack of relationship between open-angle glaucoma and choroidal thickness is suggested.
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