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Trabecular Meshwork Response to Pressure Elevation in the Living Human Eye
Published on: June 20, 2015
Relationship between intraocular pressure and angle configuration: an anterior segment OCT study
Rachel S Chong1, Lisandro M Sakata, Arun K Narayanaswamy
1Singapore Eye Research Institute and Singapore National Eye Centre, 11 Third Hospital Avenue, Singapore.
Investigative Ophthalmology & Visual Science
|January 10, 2013
Summary
This study found that increased anterior chamber angle closure, measured by gonioscopy and AS-OCT, is associated with higher intraocular pressure (IOP). Understanding this link is crucial for managing glaucoma risk.
Area of Science:
- Ophthalmology
- Glaucoma Research
- Anterior Segment Imaging
Background:
- Intraocular pressure (IOP) is a key risk factor for glaucoma.
- Anterior chamber angle (ACA) configuration influences aqueous humor outflow.
- Accurate assessment of ACA is vital for glaucoma diagnosis and management.
Purpose of the Study:
- To evaluate the correlation between intraocular pressure (IOP) and anterior chamber angle (ACA) configuration.
- To compare ACA assessments using gonioscopy and anterior segment optical coherence tomography (AS-OCT).
Main Methods:
- 2045 subjects (≥50 years) underwent AS-OCT, Goldmann applanation tonometry, and gonioscopy.
- Angle closure defined by inability to visualize posterior trabecular meshwork (gonioscopy) or iris-angle wall contact (AS-OCT).
- AS-OCT parameters measured using specialized software; IOP adjusted for confounding factors.
Main Results:
- IOP significantly increased with the number of closed quadrants on both gonioscopy and AS-OCT (P < 0.001).
- Higher IOP correlated with most quantitative AS-OCT ACA parameters, excluding iris thickness and lens vault.
- Mean IOP was 14.8 ± 2.4 mm Hg; increased closure extent showed higher mean IOP.
Conclusions:
- A significant association exists between the degree of angle closure and elevated intraocular pressure.
- Both gonioscopy and AS-OCT effectively demonstrate the relationship between ACA configuration and IOP.
- Findings highlight the importance of ACA assessment in managing IOP and glaucoma.
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