Related Experiment Video
Updated: May 14, 2026
04:02
Serial Two-Photon Tomography of the Whole Marmoset Brain for Neuroanatomical Analyses
Published on: January 17, 2025
Single shot whole brain imaging using spherical stack of spirals trajectories.
Jakob Assländer1, Benjamin Zahneisen, Thimo Hugger
1Department of Radiology, Medical Physics, University Medical Center Freiburg, Breisacher Str. 60a, 79106 Freiburg, Germany. jakob.asslaender@uniklinik-freiburg.de
Neuroimage
|February 7, 2013
Summary
MR-encephalography enables brain functional signal observation at 10 Hz, filtering noise for event detection. A novel spherical stack of spirals trajectory minimizes spatial information loss in areas with susceptibility gradients.
Area of Science:
- Neuroimaging
- Medical Physics
- Biophysics
Background:
- MR-encephalography (MRE) offers high temporal resolution for brain functional imaging.
- Conventional MRE techniques face challenges with off-resonance artifacts due to long readout times.
- Physiological noise and single event activations require advanced imaging methods.
Purpose of the Study:
- To introduce and evaluate a spherical stack of spirals trajectory for MR-encephalography.
- To address off-resonance artifacts in high temporal resolution MRE.
- To improve spatial information preservation in challenging brain regions.
Main Methods:
- Development of a spherical stack of spirals trajectory for 3D-encoded MRE.
- Utilizing undersampled non-Cartesian trajectories and parallel imaging.
- Regularized image reconstruction techniques applied to MRE data.
- Analysis of k-space trajectories in regions of susceptibility gradients.
Main Results:
- The proposed spherical stack of spirals trajectory effectively reduces off-resonance artifacts.
- Spatial information loss in areas with strong susceptibility gradients is significantly decreased compared to concentric shells.
- High temporal resolution (10 Hz) functional signal observation is maintained.
- Meaningful image reconstruction is improved in challenging anatomical locations.
Conclusions:
- The spherical stack of spirals trajectory is a promising advancement for MR-encephalography.
- This method enhances the feasibility of high temporal resolution neuroimaging.
- It offers improved image quality and reliability in the presence of magnetic field inhomogeneities.
