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Updated: May 11, 2026

Translational Brain Mapping at the University of Rochester Medical Center: Preserving the Mind Through Personalized Brain Mapping
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Translational Brain Mapping at the University of Rochester Medical Center: Preserving the Mind Through Personalized Brain Mapping

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Multicenter R2* mapping in the healthy brain.

Stefan Ropele1, Mike P Wattjes, Christian Langkammer

  • 1Department of Neurology, Medical University of Graz, Graz, Austria.

Magnetic Resonance in Medicine
|May 10, 2013
PubMed
Summary
This summary is machine-generated.

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R2* mapping is a reliable method for measuring brain iron accumulation across different scanners. Standardization of MRI protocols is key for consistent results in multicenter studies.

Area of Science:

  • Neuroimaging
  • Biomarkers
  • Iron Metabolism

Background:

  • R2* relaxation rate mapping is a sensitive indicator of brain iron accumulation.
  • Assessing the variability of R2* mapping is crucial for its clinical application.

Purpose of the Study:

  • Evaluate inter-scanner and inter-subject variability of R2* mapping.
  • Examine the relationship between brain volume and R2* in deep gray matter structures.

Main Methods:

  • Multi-center study involving 81 healthy subjects across seven different 3 T MRI systems.
  • R2* mapping performed using a dual-echo gradient echo sequence.
  • Variability assessed using coefficient of variation, with and without age correction.

Main Results:

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  • Inter-center variability of R2* was low (<5.6%) after age correction, significantly lower than intra-subject variability (6.7%-11.7%).
  • R2* in the putamen and red nucleus correlated positively with cortical volume.
  • R2* in the globus pallidus and substantia nigra showed a negative association with white matter volume.

Conclusions:

  • R2* mapping is a robust and reproducible measure in multicenter settings when standardized MRI protocols are employed.
  • Further research is needed to understand the link between deep gray matter iron concentration and specific brain compartment volumes.