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Updated: May 9, 2026

Breathing-controlled Electrical Stimulation (BreEStim) for Management of Neuropathic Pain and Spasticity
Published on: January 10, 2013
A dual-mode highly efficient class-E stimulator controlled by a low-Q class-E power amplifier through duty cycle
Hung-Wei Chiu1, Chien-Chi Lu, Jia-min Chuang
1Department of Electronic Engineering and Graduate Institute of Computer and Communication Engineering, National Taipei University of Technology, Taipei 10608, Taiwan. hwchiu@ntut.edu.tw
This study introduces high-efficiency class-E amplifiers for implantable electrical stimulation systems, using sine-wave pulsed radiofrequency (PRF) for superior pain relief. The novel design achieves high efficiency in both low and high voltage modes.
Area of Science:
- Electrical Engineering
- Biomedical Engineering
- Power Electronics
Background:
- Implantable electrical stimulation systems require efficient power amplifiers.
- Sine-wave pulsed radiofrequency (PRF) stimulation shows superior efficacy for pain relief compared to square waves.
- Existing class-E amplifiers face challenges in achieving high efficiency across different voltage modes.
Purpose of the Study:
- To design and present two high-efficiency class-E amplifiers for implantable electrical stimulation.
- To enable sine-wave PRF stimulation for enhanced pain relief.
- To achieve high DC-AC conversion efficiency in both low-voltage and high-voltage modes.
Main Methods:
- Developed a duty-cycle-controlled class-E PRF driver with a high-Q factor.
- Implemented two operational modes (LV and HV) using a single switched series inductor and an unchanged parallel capacitor.
- Utilized a duty-cycle detector and a complementary low-Q class-E power amplifier (PA) for inductive control.
- Presented a design methodology for a low-Q inductive interface for non-50% duty cycles.
Main Results:
- Achieved 91% efficiency at 0.98 V output in LV mode (22% duty cycle).
- Achieved 92% efficiency at 2.95 V output in HV mode (47% duty cycle).
- A 1.5-V PA delivered 2.9-V sine wave to a 500 Ω load with 14.21 mW DC power consumption.
- Obtained optimal 60% drain efficiency at a 10-mm coupling distance.
Conclusions:
- The proposed duty-cycle-controlled class-E PRF driver effectively delivers high-efficiency sine-wave stimulation for implantable systems.
- The dual-mode operation and inductive control mechanism enable versatile and efficient power delivery.
- The design methodology facilitates the development of efficient inductive interfaces for non-conventional duty cycles in biomedical applications.
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