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Inotropic effect of dopamine on rat heart during postnatal ontogeny
G A Bilalova1, L M Kazanchikova, T L Zefirov
1Department of Anatomy, Physiology, and Human Health Care, Kazan Federal University, Kazan, Russia. g.bilalova@mail.ru.
Abstract:
We studied the effect of dopamine in concentrations of 10(-9), 10(-8), 10(-7), 10(-6), and 10(-5) M on contraction strength of isolated myocardial strips from the right atrium and right ventricle of rats aging 21, 42, 56, and 100 days. Dopamine in a concentration of 10(-9) M had a positive inotropic effect in rats of various ages. Increasing the concentration of dopamine to 10(-7)-10(-5) M was accompanied by a negative inotropic effect on the heart.
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