Related Experiment Video
Updated: Apr 23, 2026

07:09
The Sciatic Nerve Cuffing Model of Neuropathic Pain in Mice
Published on: July 16, 2014
51.2K
Introduction to neuropathic pain syndromes
Juanmarco Gutierrez1, Sukreet Raju1, Jonathan P Riley1
1Department of Neurosurgery, School of Medicine, Emory University, 101 Woodruff Circle, Lab 6339, Atlanta, GA 30322, USA.
Neurosurgery Clinics of North America
|September 22, 2014
Summary
Chronic pain affects millions, causing significant economic burden and impacting quality of life. This review covers craniofacial, spinal, and peripheral neuropathic pain, highlighting the need for better data and classification.
Area of Science:
- Neurology
- Pain Medicine
- Epidemiology
Background:
- Chronic pain significantly impairs quality of life and poses a major challenge to healthcare.
- Neuropathic pain syndromes, including craniofacial, spinal, and peripheral types, represent a substantial economic burden, costing the US over $600 billion annually.
- Current understanding of chronic pain epidemiology and treatment outcomes is limited.
Purpose of the Study:
- To provide an overview of the epidemiology, clinical presentation, and treatment outcomes for craniofacial, spinal, and peripheral neuropathic pain syndromes.
- To emphasize the clinical challenges in diagnosing and treating chronic neuropathic pain.
- To highlight the urgent need for standardized classification and improved data.
Main Methods:
- Literature review and synthesis of existing data on chronic pain syndromes.
- Analysis of epidemiological data, clinical presentations, and treatment outcomes.
- Identification of gaps in current knowledge and practice.
Main Results:
- Chronic pain syndromes are widespread and impose a significant economic burden.
- Craniofacial, spinal, and peripheral neuropathic pain have distinct epidemiological and clinical characteristics.
- Treatment outcomes for chronic neuropathic pain are variable and often suboptimal.
Conclusions:
- Standardized classification systems are crucial for accurate diagnosis and effective management of chronic pain.
- Improved epidemiologic data collection is necessary to understand the true prevalence and impact of these conditions.
- Reliable treatment outcomes data are essential for evidence-based clinical practice and future research.
More Related Videos
Related Concept Videos
Analgesia and Pain Management
3.2K
Pain is critical to various clinical pathologies, provoking an urgent need for effective management. Pain, whether acute or chronic, is a complex neurochemical process. Its alleviation depends on the type, with nonopioid analgesics effective for mild to moderate pain, such as musculoskeletal or inflammatory pain, while neuropathic pain responds best to anticonvulsants, tricyclic antidepressants, or serotonin/norepinephrine reuptake inhibitors. For severe acute or chronic pain, opioids may be...
3.2K
Pain
2.0K
Pain serves as a critical warning signal that alerts the body to potential or actual harm. When mechanical pressure on the skin is intense, such as from a sharp pinch, the sensation transitions from touch to pain. Similarly, extreme temperatures, like a hot pot handle, convert the sensation of heat into pain. Pain can also result from overstimulation of other senses, such as blinding light, loud noise, or the intense heat from habañero peppers. This ability to sense pain is essential for...
2.0K
Nociception
28.3K
Nociception—the ability to feel pain—is essential for an organism’s survival and overall well-being. Noxious stimuli such as piercing pain from a sharp object, heat from an open flame, or contact with corrosive chemicals are first detected by sensory receptors, called nociceptors, located on nerve endings. Nociceptors express ion channels that convert noxious stimuli into electrical signals. When these signals reach the brain via sensory neurons, they are perceived as pain.
28.3K
Diabetic Neuropathy
35
DefinitionDiabetic neuropathy is nerve damage caused by long-standing diabetes mellitus. It results directly from prolonged high blood sugar levels.PathophysiologyThe pathophysiology of diabetic neuropathy involves both metabolic and vascular disturbances triggered by chronic hyperglycemia.Metabolic injury: Elevated glucose levels activate the polyol pathway within nerve cells, leading to the accumulation of sorbitol and fructose. This increases oxidative stress, disrupts normal nerve...
35
Overview of Somatic Sensory Pathways
9.8K
Somatic sensory or somatosensory pathways refer to the neural pathways that carry information related to touch, pressure, pain, temperature, and proprioception from the skin, muscles, tendons, and joints to the brain. These pathways involve several stages of processing and integration of sensory information.
The somatosensory system is divided into three main pathways: the dorsal (or posterior) column-medial lemniscus, spinothalamic (or anterolateral), and spinocerebellar pathways.
The dorsal...
The somatosensory system is divided into three main pathways: the dorsal (or posterior) column-medial lemniscus, spinothalamic (or anterolateral), and spinocerebellar pathways.
The dorsal...
9.8K
Degenerative Disc Disease ll: Pathophysiology
19
The symptoms of degenerative disc disease arise from a combination of mechanical compression, vascular compromise, and biochemical inflammation, which together disrupt nerve function and produce pain.Mechanical CompressionDisc degeneration reduces height and elasticity, predisposing to herniation of the nucleus pulposus, a major cause of radicular pain. Herniations may be protrusion (bulging with intact annulus), extrusion (nucleus extends beyond disc but remains connected), or sequestration...
19

