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A 16 × 16 CMOS Capacitive Biosensor Array Towards Detection of Single Bacterial Cell.
IEEE Transactions on Biomedical Circuits and Systems
|May 15, 2015
Summary
This study introduces a novel 16x16 CMOS biosensor array for detecting whole-cell bacteria using impedance measurements. The developed biosensor achieves a low detection limit for Staphylococcus epidermidis, enabling portable point-of-care diagnostics.
Area of Science:
- Biomedical Engineering
- Electrical Engineering
- Materials Science
Background:
- Whole-cell bacteria detection is crucial for diagnostics.
- Existing biosensor technologies face limitations in sensitivity and portability.
Purpose of the Study:
- To develop a high-sensitivity CMOS biosensor array for impedance-based whole-cell bacteria detection.
- To demonstrate the feasibility of the biosensor for point-of-care applications.
Main Methods:
- Fabrication of a 16x16 CMOS biosensor array with microelectrodes and a charge-sharing readout interface.
- Experimental characterization of dielectric measurements and Staphylococcus epidermidis detection.
- Modeling and simulation of the sensor and circuit system.
Main Results:
- The biosensor array achieved accurate dielectric measurements up to 0.05 S/m conductivity.
- Maximal sensitivity of 55 mV/fF and a signal-to-noise ratio (SNR) of 37 dB were recorded.
- Real-time detection of Staphylococcus epidermidis with a limit of ~7 bacteria per pixel and sensitivity of 2.18 mV/cell was demonstrated.
Conclusions:
- The developed CMOS biosensor array offers high sensitivity and a low detection limit for bacterial cells.
- The sensor is suitable for portable point-of-care (PoC) diagnosis tools and lab-on-chip (LoC) systems due to its small size and low power consumption.
