[TISSUE BLOOD FLOW IN THE DIGESTIVE ORGANS OF RATS WITH ACUTE PANCREATITIS AFTER CORVITIN ADMINISTRATION]

Area of Science:

• Biochemistry
• Pharmacology
• Gastroenterology

Context:

• Acute pancreatitis (AP) induced by L-arginine in rats significantly reduces blood flow in the pancreas, liver, and gastric mucosa.
• Blood flow reductions were most pronounced in the gastric mucosa (64%) and liver (61%), with a 42% decrease in the pancreas.

Purpose:

• To investigate the therapeutic effect of Corvitin (a modified quercetin) on L-arginine-induced acute pancreatitis in rats.
• To assess Corvitin's impact on restoring blood flow rates in the pancreas, liver, and gastric mucosa.

Summary:

• Corvitin administration (5 mg/kg/day from day 11 to 20) significantly promoted blood flow recovery in all investigated organs.
• Full recovery was observed in the pancreas, near-complete recovery in the liver, and partial recovery in the gastric mucosa.

Impact:

• Corvitin demonstrates potential for correcting blood flow disturbances in digestive organs during acute pancreatitis.
• The findings suggest Corvitin can improve organ function and accelerate recovery in early-stage AP.