EXOCRINE FUNCTION OF THE LIVER IN RATS WITH EXPOSURE TO CОRVITIN.

Area of Science:

• Hepatology
• Pharmacology
• Biochemistry

Background:

• Bile secretion is crucial for digestion and detoxification.
• Flavonoids, like quercetin, are known for their diverse biological activities.
• Understanding the effects of novel compounds on liver function is essential.

Purpose of the Study:

• To investigate the impact of Corvitin, a water-soluble quercetin analogue, on bile secretion in rats.
• To analyze Corvitin's effect on bile acid composition and conjugation processes.
• To determine the dose-dependent effects of Corvitin on hepatic exocrine function.

Main Methods:

• Acute experiments on rats with cannulated bile ducts.
• Intraportal administration of Corvitin at varying doses (2.5, 5, 10 mg/kg).
• Thin-layer chromatography to assess bile acid conjugation and concentrations.

Main Results:

• Corvitin significantly increased bile secretion volume by 20.9-31.2% compared to controls.
• A mild stimulating effect on bile acid conjugation with taurine and glycine was observed, particularly at 5 mg/kg.
• Corvitin altered the concentrations of specific bile acids, increasing glycochenodeoxycholic and glycodeoxycholic acids, and free cholic, chenodeoxycholic, and deoxycholic acids at higher doses.

Conclusions:

• Corvitin modulates the exocrine function of the liver.
• It enhances bile secretion and alters bile acid profiles in a dose-dependent manner.
• Corvitin's effects on bile acid conjugation highlight its potential as a modulator of liver metabolism.