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Retrieving GPCR data from public databases.

Christopher Southan1

  • 1IUPHAR/BPS Guide to Pharmacology, Centre for Integrative Physiology, University of Edinburgh, EH8 9XD, UK.

Current Opinion in Pharmacology
|July 30, 2016
PubMed
Summary
This summary is machine-generated.

This review highlights key databases and portals for G protein-coupled receptor (GPCR) research, offering examples of their utility. It emphasizes utilizing these resources alongside recent publications for comprehensive GPCR project data discovery.

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Area of Science:

  • Biochemistry
  • Pharmacology
  • Bioinformatics

Background:

  • Databases have significantly advanced G protein-coupled receptor (GPCR) research.
  • Access to curated GPCR data is crucial for researchers.

Purpose of the Study:

  • To provide an overview of available GPCR data resources.
  • To illustrate the practical applications of these databases and portals in GPCR research.

Main Methods:

  • Review of major databases: UniProt (proteins), Ensembl (genes), ChEMBL (bioactive chemistry), SureChEMBL (patents).
  • Outline of expert-annotated portals: GPCRdb (structures, sequences, mutations) and IUPHAR/BPS Guide to PHARMACOLOGY (GtoPdb) (ligands, drugs, pharmacology).

Main Results:

  • Identified key databases and portals offering diverse GPCR information.
  • Demonstrated utility examples for accessing protein, gene, chemical, patent, structural, and pharmacological data.
  • Highlighted GPCRdb's focus on structural and sequence data, and GtoPdb's on pharmacology and drug information.

Conclusions:

  • Researchers should leverage these databases and portals for GPCR projects.
  • The accelerating growth of data necessitates checking databases and recent publications.
  • Integrated use of diverse data sources enhances GPCR research discovery.