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Updated: Mar 11, 2026
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Capturing Actively Produced Microbial Volatile Organic Compounds from Human-Associated Samples with Vacuum-Assisted Sorbent Extraction
Published on: June 1, 2022
4.6K
Saliva - Volatile Biomarkers and Profiles.
Maciej Milanowski1,2, Paweł Pomastowski1,2, Tomasz Ligor1,2
1a Department of Environmental Chemistry and Bioanalytics , Faculty of Chemistry, Nicolaus Copernicus University , Toruń , Poland.
Critical Reviews in Analytical Chemistry
|December 2, 2016
Summary
Saliva contains volatile organic compounds (VOCs) that can indicate diseases like halitosis and periodontal disease. This review explores salivary VOCs as potential biomarkers for health and disease monitoring.
Area of Science:
- Oral biology
- Biochemistry
- Analytical chemistry
Background:
- Saliva is crucial for oral health, containing complex molecular constituents.
- Volatile organic compounds (VOCs) in saliva originate from blood, bacterial metabolism, breath, and diet.
- Certain VOCs are potential biomarkers for diseases and occupational exposures.
Purpose of the Study:
- To review the fundamental roles and composition of saliva.
- To present methodologies for sampling, extraction, and enrichment of salivary VOCs.
- To review literature on salivary VOC profiling and biomarker discovery.
Main Methods:
- Literature review of existing studies on salivary VOCs.
- Compilation of reported VOCs and potential biomarkers from saliva.
- Discussion of analytical techniques for VOC analysis.
Main Results:
- Saliva's basic functions and composition are detailed.
- Methodologies for salivary VOC analysis are presented.
- Extensive tables of identified VOCs and potential biomarkers are included.
Conclusions:
- Salivary VOCs represent a promising, non-invasive source for disease biomarker discovery.
- Further research into salivary VOC profiling can enhance diagnostic capabilities.
- This review provides a comprehensive resource for understanding salivary VOCs.
