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Demineralized Xenogenic Dentin and Autogenous Bone as Onlay Grafts to Rabbit Tibia
Adel Al-Asfour1, Payam Farzad, Ala Al-Musawi
1*Associate Professor, Department of Surgical Sciences, Faculty of Dentistry, Kuwait University, Kuwait City, Kuwait. †PhD Student, Department of Biomaterials, Institute for Surgical Sciences, The Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden; Consultant, Department of Oral & Maxillofacial Surgery, Karolinska University Hospital, Stockholm, Sweden. ‡Professor, Department of Biomaterials, Institute for Surgical Sciences, The Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden; Consultant, Department of ENT and Oral & Maxillofacial Surgery, NU Hospital [LINE SEPARATOR]Organization, Trollhättan, Sweden. §Professor, Department of Surgical Sciences, Faculty of Dentistry, Kuwait University, Kuwait City, Kuwait.
Demineralized xenogenic dentin onlay grafts and autogenous bone grafts showed similar resorption rates over 12 weeks in rabbit tibias. Both graft types integrated with host bone, demonstrating comparable healing patterns and bone formation at the interface.
Area of Science:
- Biomaterials Science
- Regenerative Medicine
- Orthopedic Surgery
Background:
- Bone grafting is crucial for skeletal defect repair.
- Autogenous bone grafts are the gold standard but have limitations.
- Xenogenic materials offer potential alternatives for bone regeneration.
Purpose of the Study:
- To compare the healing patterns of demineralized xenogenic dentin onlay grafts with autogenous bone grafts.
- To evaluate the resorption characteristics and bone integration of these graft materials in a rabbit tibia model.
Main Methods:
- Eight 6-month-old male New Zealand rabbits were used.
- Standardized dentin blocks (human premolars) and autogenous bone blocks (tibia) were grafted as onlay grafts.
- Grafts were assessed after a 12-week healing period.
Main Results:
- Both graft types showed fusion, resorption, and replacement by bone and connective tissue.
- Grafts were reduced to approximately one-third of their original size after 12 weeks.
- Bone formation was observed within resorption cavities in dentin grafts and at the graft-host interface for both types.
Conclusions:
- Demineralized xenogenic dentin onlay grafts exhibit similar resorption rates to autogenous bone grafts over 12 weeks.
- New bone formation primarily occurred at the interface between the graft and native bone, involving replacement resorption.
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