Comparison Between Spectral-Domain and Swept-Source Optical Coherence Tomography Angiographic Imaging of Choroidal...

Area of Science:

• Ophthalmology
• Medical Imaging
• Biomedical Engineering

Background:

• Choroidal neovascularization (CNV) is a key factor in several retinal diseases.
• Accurate imaging of CNV is crucial for diagnosis and treatment monitoring.
• Optical coherence tomography angiography (OCTA) offers non-invasive visualization of retinal vasculature.

Purpose of the Study:

• To compare the imaging performance of swept-source OCTA (SS-OCTA) and spectral-domain OCTA (SD-OCTA) for choroidal neovascularization (CNV).
• To evaluate differences in lesion area measurements between SS-OCTA and SD-OCTA across different scan sizes.

Main Methods:

• OCTA was performed using both SS-OCTA (100 kHz) and SD-OCTA (68 kHz) instruments.
• Both 3x3 mm and 6x6 mm scan areas were acquired for each instrument.
• Choroidal neovascularization lesion areas were manually outlined by two graders and compared between the two OCTA technologies.

Main Results:

• Analysis included 27 eyes from 23 patients with CNV.
• For 3x3 mm scans, mean CNV areas were 1.17 mm² (SS-OCTA) and 1.01 mm² (SD-OCTA) (P=0.047).
• For 6x6 mm scans, mean CNV areas were significantly larger with SS-OCTA (1.24 mm²) compared to SD-OCTA (0.74 mm²) (P=0.003).

Conclusions:

• CNV lesion areas tended to be larger when imaged with SS-OCTA compared to SD-OCTA.
• The discrepancy in measured CNV area between SS-OCTA and SD-OCTA was more significant for larger 6x6 mm scans.
• These findings suggest SS-OCTA may provide a more comprehensive assessment of CNV size, particularly in larger lesions.