Related Experiment Video

Updated: Feb 10, 2026

Treatment of Osteochondral Defects in the Rabbit's Knee Joint by Implantation of Allogeneic Mesenchymal Stem Cells in Fibrin Clots
11:22

Treatment of Osteochondral Defects in the Rabbit's Knee Joint by Implantation of Allogeneic Mesenchymal Stem Cells in Fibrin Clots

Published on: May 21, 2013

18.0K

Advances for Treatment of Knee OC Defects

Marta Ondrésik1,2, J Miguel Oliveira3,4,5, Rui L Reis3,4,5

  • 13B's Research Group - Biomaterials, Biodegradables and Biomimetics, University of Minho, Headquarters of the European Institute of Excellence on Tissue Engineering and Regenerative Medicine, Barco, Guimarães, Portugal. marta.ondresik@dep.uminho.pt.

Advances in Experimental Medicine and Biology
|May 9, 2018
PubMed

Insights

Osteochondral defects in young adults often go undetected and fail to heal. Tissue engineering and regenerative medicine offer promising solutions for repairing these injuries and preventing osteoarthritis.

Area of Science:

  • Orthopedics and Regenerative Medicine

Background:

  • Osteochondral (OC) defects are common in young adults and have poor natural healing capacity.
  • Early detection of OC defects is crucial but challenging, impacting treatment outcomes.
  • Existing repair methods lack regenerative potential and long-term efficacy.

Purpose of the Study:

  • To overview current tissue engineering and regenerative medicine strategies for osteochondral defect management.
  • To review stem cell sources for sustainable cell-based therapies.
  • To discuss scaffolding materials mimicking the native osteochondral unit.

Main Methods:

  • Literature review of tissue engineering and regenerative medicine approaches for OC defects.
  • Analysis of stem cell types for regenerative potential.
  • Evaluation of biomaterial scaffolds for OC repair.

Main Results:

  • Tissue engineering and regenerative medicine present promising avenues for OC defect treatment.
  • Various stem cell types offer alternatives to autologous chondrocytes, addressing limitations.
  • Scaffolding materials are being developed to mimic native tissue properties.

Conclusions:

  • Regenerative approaches hold significant potential for treating osteochondral defects.
  • Stem cells and advanced biomaterials are key components in developing effective OC repair strategies.
  • Further research aims to restore joint function and prevent osteoarthritis progression.
Keywords:
ChondrocytesOsteochondral defectsOsteochondral tissue engineeringRegenerative medicineScaffold designStem cell therapyand Bilayered scaffoldsiPS cells

More Related Videos

Author Spotlight: Minimally Invasive Ultrasound-Guided Acupotomy in Knee Osteoarthritis Treatment04:57

Author Spotlight: Minimally Invasive Ultrasound-Guided Acupotomy in Knee Osteoarthritis Treatment

Published on: April 26, 2024

1.3K
Preparation, Procedures and Evaluation of Platelet-Rich Plasma Injection in the Treatment of Knee Osteoarthritis14:38

Preparation, Procedures and Evaluation of Platelet-Rich Plasma Injection in the Treatment of Knee Osteoarthritis

Published on: January 4, 2019

19.4K

Related Concept Videos

Knee Joint01:23

Knee Joint

The knee joint is the most complicated joint in the body. It consists of three articulations– two tibiofemoral and one patellofemoral. As is characteristic of synovial joints, the knee joint has a thin articular capsule that partially surrounds this joint cavity. Additionally, several ligaments, muscles, and cartilaginous structures support the movement of the knee.
A total of seven ligaments support the knee joint. The patellar ligament, which is also attached to the quadriceps femoris...
3.3K
Lumber Defects01:23

Lumber Defects

Lumber defects, which can affect both the appearance and structural integrity of wood, include a variety of growth and manufacturing flaws. Growth defects such as knots and knotholes occur where branches were once attached to the tree trunk, with knotholes forming when these knots fall out. Other natural defects include decay and insect damage, which compromise the wood's strength and durability.
Shakes are minor fractures that run along or across the wood's annual rings, while wane is...
556
Overview of Advanced Functional Groups02:22

Overview of Advanced Functional Groups


Functional groups are groups of atoms with specific chemical properties that occur within organic molecules and are sometimes denoted as “R”. Functional groups can “functionalize” a compound by enabling it to adopt different physical and chemical properties.
Types of Advanced Functional Groups
The table below summarizes some of the major functional groups in organic chemistry.
30.2K
Extraction: Advanced Methods00:56

Extraction: Advanced Methods

Metal ions can be separated from one another by complexation with organic ligands–the chelating agent– to form uncharged chelates. Here, the chelating agent must contain hydrophobic groups and behave as a weak acid, losing a proton to bind with the metal. Since most organic ligands used in this process are insoluble or undergo oxidation in the aqueous phase, the chelating agent is initially added to the organic phase and extracted into the aqueous phase. The metal-ligand complex is...
1.2K
Sample Preparation for Analysis: Advanced Techniques01:08

Sample Preparation for Analysis: Advanced Techniques

Accurate analysis of complex samples often requires advanced preparation techniques to achieve reliable and reproducible results. Samples containing inorganic or organic materials can be challenging to dissolve or decompose effectively. Standard sample preparation methods include acid digestion, fusion, dry ashing, and wet digestion.
Acid digestion with strong acids is commonly used to dissolve inorganic materials that are insoluble (do not dissolve) in water. This method can be useful for...
1.5K
Cardiopulmonary Resuscitation V: Advanced Airway Management Techniques01:30

Cardiopulmonary Resuscitation V: Advanced Airway Management Techniques

Airway management is essential in emergency and surgical medicine, ensuring ventilation and oxygenation in patients who cannot maintain their own airway. Clinicians use a range of techniques and devices to secure the airway, depending on the patient’s condition and the clinical context. Key methods include endotracheal intubation, rapid sequence intubation (RSI), supraglottic airway devices, and advanced visualization aids. In cases where these approaches fail, surgical airway...
595