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Instrumental, optical and geometrical parameters affecting time-gated diffuse optical measurements: a systematic
Anurag Behera1, Laura Di Sieno1, Antonio Pifferi1,2
1Politecnico di Milano, Dipartimento di Fisica, Piazza Leonardo da Vinci 32, 20133 Milano, Italy.
Biomedical Optics Express
|November 22, 2018
Summary
Optimizing time-domain diffuse optics requires careful consideration of instrumental, optical, and geometrical factors. A source-detector distance of approximately 10 mm balances system non-idealities while preserving short-distance advantages.
Area of Science:
- Biomedical Optics
- Diffuse Optics
- Photonic Sensing
Background:
- Sensitivity in time-domain diffuse optics is crucial for detecting localized absorption changes within diffusive media.
- Instrumental, optical, and geometrical parameters significantly influence sensitivity, potentially limiting novel strategies like short source-detector distance measurements.
Purpose of the Study:
- To comprehensively evaluate the impact of various parameters on sensitivity in time-domain diffuse optics.
- To identify critical hardware parameters and optimal measurement strategies for enhanced detection of deep localized absorption perturbations.
Main Methods:
- Experimental measurements and simulations were employed to assess system performance.
- Standardized figures of merit, including contrast and contrast-to-noise ratio, were utilized to quantify sensitivity.
Main Results:
- The 'memory effect' was identified as the most critical hardware parameter, limiting the dynamic range.
- A source-detector distance of approximately 10 mm offers a practical compromise, mitigating non-idealities while retaining short-distance benefits.
Conclusions:
- This study provides essential guidance for users on optimal measurement conditions and strategies in diffuse optics.
- Findings will aid technology developers in identifying crucial hardware features for next-generation diffuse optics systems.
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