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Related Concept Videos

Plant Cells and Tissues02:01

Plant Cells and Tissues

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Plant tissues are collections of similar cells performing related functions. Different plant tissues will have their own specialized roles and can be combined with other tissues to form organs such as flowers, fruit, stem, and leaves. Two major types of plant tissue include meristematic and permanent tissue.
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Tissue Renewal without Stem Cells01:23

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After cellular or tissue damage, the resident stem cells present in the human body can locally repair and regenerate the damaged tissue or organ. However, even though some tissues do not have stem cells, they can repair and regenerate with the help of pre-existing cells. For example, beta cells of the pancreas and hepatocytes of the liver can divide to renew and regenerate the tissue. Here, both cell division and cell death are well regulated by homeostasis.
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Stem Cell Therapy for Tissue Regeneration01:21

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Stem cell therapy is a method used in regenerative medicine to repair and restore function to damaged tissues and organs. Stem cells have the potential to proliferate and differentiate into various tissue types, making them ideal candidates for tissue regeneration. For example, hematopoietic stem cell transplants are commonly used in blood cancer treatment to replenish damaged bone marrow and restore healthy blood cells.
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Tissues01:18

Tissues

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Cells with similar structure and function are grouped into tissues. A group of tissues with a specialized function is called an organ. There are four main types of tissue in vertebrates: epithelial, connective, muscle, and nervous.
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Tissues01:25

Tissues

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Tissues are a group of cells that share a common embryonic origin. Microscopic observation reveals that the cells in a tissue share morphological features and are arranged in an orderly pattern to perform specific functions. From an evolutionary perspective, tissues appear in more complex organisms. Although there are many types of cells in the human body, they are organized into four broad categories of tissues: epithelial, connective, muscle, and nervous. Each of these categories is...
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Bone Cells and Tissue01:30

Bone Cells and Tissue

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Bones contain a relatively small number of cells entrenched in a matrix of organic and inorganic components. Although bone cells compose only a small amount of the bone volume, they are crucial to its function. Four types of cells are found within the bone tissue— osteoblasts, osteocytes, osteogenic cells, and osteoclasts.
Osteoblasts and Osteocytes
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Two Methods for Decellularization of Plant Tissues for Tissue Engineering Applications
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Two Methods for Decellularization of Plant Tissues for Tissue Engineering Applications

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Decellularized Tissue Matrix for Stem Cell and Tissue Engineering.

Jung Seung Lee1, Yi Sun Choi1, Seung-Woo Cho2

  • 1Department of Biotechnology, Yonsei University, Seoul, South Korea.

Advances in Experimental Medicine and Biology
|November 25, 2018
PubMed
Summary
This summary is machine-generated.

Decellularization removes cells from tissues, creating immune-friendly scaffolds for tissue engineering. These decellularized matrices support cell growth and are used in regenerative medicine for organ repair and tissue regeneration.

Keywords:
Artificial organDecellularizationOrgan transplantationRegenerative medicineStem cellTissue engineering

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Area of Science:

  • Biomaterials Science
  • Regenerative Medicine
  • Tissue Engineering

Background:

  • Decellularization removes cellular components from native tissues.
  • This process reduces potential immune reactions to resulting scaffolds.
  • Decellularized matrices retain native tissue microenvironments crucial for cell function.

Purpose of the Study:

  • To review decellularized tissue matrices.
  • To highlight their applications in regenerative medicine.
  • To discuss their use in artificial organ reconstruction and tissue repair.

Main Methods:

  • Decellularization employs combinations of mechanical, chemical, and enzymatic processes.
  • Various native tissues are processed to create decellularized matrices.
  • Matrices are manipulated into different formats for specific applications.

Main Results:

  • Decellularized matrices preserve tissue-specific structural, mechanical, and biochemical properties.
  • These scaffolds promote cellular engraftment and function.
  • Diverse cell types, including stem cells, can be cultured on these matrices.

Conclusions:

  • Decellularized matrices are versatile biomaterials for tissue engineering.
  • They offer promising solutions for regenerating damaged tissues.
  • Applications include artificial organs, cell culture, and transplantation carriers.