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Updated: Jan 28, 2026
09:11
Y-90 Radioembolization and PD-1 Inhibitor as Neoadjuvant Treatment in Hepatocellular Carcinoma
Published on: May 24, 2024
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Same-Day Yttrium-90 Radioembolization: Feasibility with Resin Microspheres.
Matthew D Li1, Katrina F Chu1, Allegra DePietro2
1Division of Interventional Radiology, Department of Radiology, Massachusetts General Hospital and Harvard Medical School, 55 Fruit St., GRB 290 Boston, MA 02114.
Journal of Vascular and Interventional Radiology : JVIR
|March 2, 2019
Summary
A same-day yttrium-90 radioembolization protocol using resin microspheres is feasible for treating liver cancer. This expedited approach offers effective treatment for hepatocellular carcinoma and liver metastases.
Area of Science:
- Interventional Radiology
- Nuclear Medicine
- Oncology
Background:
- Hepatocellular carcinoma (HCC) and liver metastases require effective treatment options.
- Radioembolization with yttrium-90 (90Y) resin microspheres is an established therapy.
- Optimizing treatment delivery can improve patient outcomes and resource utilization.
Purpose of the Study:
- To assess the feasibility of a same-day 90Y radioembolization protocol.
- To evaluate this protocol for patients with HCC and liver metastases.
- To streamline the treatment process, including pretreatment angiography, lung shunt fraction (LSF) determination, and radioembolization.
Main Methods:
- Retrospective analysis of 34 same-day procedures in 26 patients (19 liver metastases, 7 HCC).
- 90Y activities calculated by body surface area method.
- Tumor response assessed by RECIST 1.1 and modified RECIST; adverse events graded per CTCAE v4.0.
Main Results:
- All planned procedures were technically successful; no cancellations due to LSF or anatomy.
- Imaging response: 25% partial response (PR) and 67% stable disease (SD) in liver metastases; 43% PR/complete response (CR) and 14% SD in HCC.
- Grade ≥ 3 adverse events in 6% of cases; mean procedure time was 4.2 hours.
Conclusions:
- A same-day 90Y radioembolization protocol with resin microspheres is feasible in select patients.
- This protocol can expedite cancer therapy delivery.
- The approach demonstrates safety and efficacy for treating liver malignancies.
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