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Updated: Jan 27, 2026

Closure of a Patent Foramen Ovale PFO: An Intervention Sequence
Published on: December 23, 2022
The Connection Between Patent Foramen Ovale and Migraine
Preetham Kumar1, Yasufumi Kijima2, Brian H West1
1Cardiology, University of California, Los Angeles, Room B-976 Factor Building, Box # 951717, Los Angeles, CA 90095-1717, USA.
Abstract:
"Observational studies have identified a relationship between patent foramen ovale (PFO) and migraine headache. In people who have migraine with aura, 40% to 60% have a PFO, compared with 20% to 30% in the general adult population. It is hypothesized that migraine, especially migraine with aura, may be triggered by hypoxemia or vasoactive chemicals (eg, serotonin), which are ordinarily metabolized during passage through the lungs. Although PFO closure is currently not a FDA-approved therapy for migraines, randomized trials suggest that this intervention may benefit a subgroup of migraineurs."
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