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Psychobiotics.
Alper Evrensel1, Barış Önen Ünsalver2, Mehmet Emin Ceylan3
1Department of Psychiatry, Uskudar University, NP Brain Hospital, Saray Mah. Ahmet Tevfik İleri Cad. No: 18 PK, 34768, Umraniye, Istanbul, Turkey. alperevrensel@gmail.com.
Advances in Experimental Medicine and Biology
|November 10, 2019
Summary
Psychobiotics, beneficial gut bacteria, show potential for treating mental health conditions like anxiety and depression. Further research is needed to explore their antipsychotic effects and full therapeutic capabilities.
Area of Science:
- Neuroscience
- Microbiology
- Psychopharmacology
Background:
- Psychobiotics are live bacteria influencing brain function via the gut microbiota.
- Preliminary studies suggest anxiolytic and antidepressant effects of psychobiotics.
- No research has explored psychobiotics for antipsychotic efficacy.
Purpose of the Study:
- To review the history of psychopharmacology and the emerging role of the gut-brain axis.
- To discuss the mechanisms of gut-brain communication influenced by psychobiotics.
- To examine the evidence for psychobiotics' metabolic, systemic, and neuropsychiatric activities.
Main Methods:
- Comprehensive review of germ-free and conventional animal experiments.
- Analysis of limited human studies on psychobiotics.
- Examination of the gut-brain axis mechanisms and psychobiotic activities.
Main Results:
- Psychobiotics demonstrate potential anxiolytic and antidepressant properties.
- The gut microbiota is increasingly recognized as a target in psychopharmacology.
- Evidence supports the metabolic, systemic, and neuropsychiatric effects of psychobiotics.
Conclusions:
- Psychobiotics hold future potential for treating neuropsychiatric disorders.
- Significant questions remain regarding their therapeutic applications.
- Further research is anticipated to address current knowledge gaps.
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