Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Evolutionary Relationships through Genome Comparisons02:54

Evolutionary Relationships through Genome Comparisons

6.8K
Genome comparison is one of the excellent ways to interpret the evolutionary relationships between organisms. The basic principle of genome comparison is that if two species share a common feature, it is likely encoded by the DNA sequence conserved between both species. The advent of genome sequencing technologies in the late 20th century enabled scientists to understand the concept of conservation of domains between species and helped them to deduce evolutionary relationships across diverse...
6.8K
RNA-seq03:21

RNA-seq

11.6K
RNA sequencing, or RNA-Seq, is a high-throughput sequencing technology used to study the transcriptome of a cell. Transcriptomics helps to interpret the functional elements of a genome and identify the molecular constituents of an organism. Additionally, it also helps in understanding the development of an organism and the occurrence of diseases. 
Before the discovery of RNA-seq, microarray-based methods and Sanger sequencing were used for transcriptome analysis. However, while...
11.6K
Genomics02:02

Genomics

39.5K
Genomics is the science of genomes: it is the study of all the genetic material of an organism. In humans, the genome consists of information carried in 23 pairs of chromosomes in the nucleus, as well as mitochondrial DNA. In genomics, both coding and non-coding DNA is sequenced and analyzed. Genomics allows a better understanding of all living things, their evolution, and their diversity. It has a myriad of uses: for example, to build phylogenetic trees, to improve productivity and...
39.5K
Comparing Copy Number Variations and SNPs02:26

Comparing Copy Number Variations and SNPs

18.5K
Sequencing of the human genome has opened up several best-kept secrets of the genome. Scientists have identified thousands of genome variations that exist within a population. These variations can be a single nucleotide or a larger chromosomal variation.
Copy number variations or CNVs are the structural variations that cover more than 1kb of DNA sequence. The single nucleotide polymorphism (SNP), on the other hand, is a single nucleotide change or a point mutation that is found in more than 1%...
18.5K
Genomic DNA in Eukaryotes00:58

Genomic DNA in Eukaryotes

52.0K
Eukaryotes have large genomes compared to prokaryotes. To fit their genomes into a cell, eukaryotic DNA is packaged extraordinarily tightly inside the nucleus. To achieve this, DNA is tightly wound around proteins called histones, which are packaged into nucleosomes that are joined by linker DNA and coil into chromatin fibers. Additional fibrous proteins further compact the chromatin, which is recognizable as chromosomes during certain phases of cell division.
52.0K
DNA Microarrays02:34

DNA Microarrays

20.5K
Microarrays are high-throughput and relatively inexpensive assays that can be automated to analyze large quantities of data at a time. They are used in genome-wide studies to compare gene or protein expression under two varied conditions, such as healthy and diseased states. Microarrays consist of glass or silica slides on which probe molecules are covalently attached through surface functionalization. Most commonly, the slides are prepared through the chemisorption of silanes to silica...
20.5K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

A Progressive Feature Learning Network for <i>Cordyceps sinensis</i> Image Recognition.

Sensors (Basel, Switzerland)·2025
Same author

Inactivation of two SARS-CoV-2 virus surrogates by electron beam irradiation on large yellow croaker slices and their packaging surfaces.

Food control·2022
Same author

Diamond-Blackfan anaemia caused by a de novo initiation codon mutation resulting in a shorter isoform of GATA1.

Clinical genetics·2022
Same author

A Deep Learning Model Incorporating Knowledge Representation Vectors and Its Application in Diabetes Prediction.

Disease markers·2022
Same author

Pnpla5-knockout rats exhibit reduced expression levels of proteins involved in steroid metabolism and wound healing compared to wild-type rats.

BMC genomics·2022
Same author

Nucleosome-Omics: A Perspective on the Epigenetic Code and 3D Genome Landscape.

Genes·2022
Same journal

Resveratrol Mitigates Noise-Induced Cochlear Damage and Delays Hearing Loss in Wistar Rats.

BioMed research international·2026
Same journal

RETRACTION: Green Fabrication of Silver Nanoparticles Using Euphorbia Serpens Kunth Aqueous Extract, their Characterization, and Investigation of its in Vitro Antioxidative, Antimicrobial, Insecticidal, and Cytotoxic Activities.

BioMed research international·2026
Same journal

Predictors of Prolonged Hospital Length of Stay in Patients With Odontogenic Infections in Ghana.

BioMed research international·2026
Same journal

Traditional Chinese Medicine Bone-Setting Techniques Research Progress for the Treatment of Knee Osteoarthritis.

BioMed research international·2026
Same journal

RETRACTION: miR-375 Inhibits the Proliferation and Invasion of Nasopharyngeal Carcinoma Cells by Suppressing PDK1.

BioMed research international·2026
Same journal

Exploring the Therapeutic Potential of Nobiletin in Nonsmall Cell Lung Cancer.

BioMed research international·2026
See all related articles

Related Experiment Video

Updated: Dec 31, 2025

Technical Demonstration of Whole Genome Array Comparative Genomic Hybridization
16:37

Technical Demonstration of Whole Genome Array Comparative Genomic Hybridization

Published on: August 5, 2008

13.2K

HRCM: An Efficient Hybrid Referential Compression Method for Genomic Big Data.

Haichang Yao1,2, Yimu Ji1,3,4, Kui Li1

  • 1School of Computer Science, Nanjing University of Posts and Telecommunications, Nanjing 210023, China.

Biomed Research International
|January 10, 2020
PubMed
Summary
This summary is machine-generated.

A new hybrid referential compression method (HRCM) offers improved efficiency for FASTA genome sequences. This lossless compression technique enhances storage and transmission, outperforming existing methods for genomic data.

More Related Videos

Array Comparative Genomic Hybridization Array CGH for Detection of Genomic Copy Number Variants
09:16

Array Comparative Genomic Hybridization Array CGH for Detection of Genomic Copy Number Variants

Published on: February 21, 2015

20.3K
Genomic MRI - a Public Resource for Studying Sequence Patterns within Genomic DNA
12:36

Genomic MRI - a Public Resource for Studying Sequence Patterns within Genomic DNA

Published on: May 9, 2011

10.5K

Related Experiment Videos

Last Updated: Dec 31, 2025

Technical Demonstration of Whole Genome Array Comparative Genomic Hybridization
16:37

Technical Demonstration of Whole Genome Array Comparative Genomic Hybridization

Published on: August 5, 2008

13.2K
Array Comparative Genomic Hybridization Array CGH for Detection of Genomic Copy Number Variants
09:16

Array Comparative Genomic Hybridization Array CGH for Detection of Genomic Copy Number Variants

Published on: February 21, 2015

20.3K
Genomic MRI - a Public Resource for Studying Sequence Patterns within Genomic DNA
12:36

Genomic MRI - a Public Resource for Studying Sequence Patterns within Genomic DNA

Published on: May 9, 2011

10.5K

Area of Science:

  • Genomics
  • Bioinformatics
  • Data Compression

Background:

  • Genome sequencing generates vast amounts of data, posing storage and transmission challenges.
  • FASTA format is widely used for genome sequences but existing compression methods have limitations in efficiency and robustness.
  • Reducing genomic data storage and transmission costs is crucial for advancing genomic technology.

Purpose of the Study:

  • To propose a novel hybrid referential compression method (HRCM) for FASTA genome sequences.
  • To improve the efficiency, robustness, and practicability of genomic data compression.
  • To reduce the storage and transmission costs of genomic data.

Main Methods:

  • Developed a hybrid referential compression method (HRCM).
  • Implemented HRCM in three stages: sequence information extraction, matching, and encoding.
  • HRCM is a lossless compression method applicable to single and multiple sequences.

Main Results:

  • HRCM demonstrates superior performance in genome batch compression compared to existing methods.
  • The method achieves high compression ratios and speeds.
  • HRCM exhibits low memory consumption, suitable for standard PCs.

Conclusions:

  • HRCM is an effective lossless compression method for FASTA genome sequences.
  • The proposed method significantly improves upon existing genome compression techniques.
  • HRCM offers a practical solution for managing large-scale genomic data efficiently.