Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Treatment for Pulmonary Arterial Hypertension: Phosphodiesterase Inhibitors01:28

Treatment for Pulmonary Arterial Hypertension: Phosphodiesterase Inhibitors

454
Phosphodiesterase 5 (PDE5) inhibitors are potent enzymes that function to hydrolyze cyclic nucleotides to their corresponding 5' monophosphates. Their unique biochemical properties have been applied in treating Pulmonary Arterial Hypertension (PAH).
Among the PDE5 inhibitors, sildenafil (Revatio) stands out as a competitive and selective inhibitor. It operates by elevating cellular levels of cGMP and augmenting signaling through the cGMP-PKG pathway, promoting vasodilation. Upon oral...
454
Disorders of the Male Reproductive System01:20

Disorders of the Male Reproductive System

3.9K
Men's health issues are increasingly recognized as significant, with several conditions posing common threats. Among these, testicular cancer is especially prevalent in younger men, particularly those aged 20 to 35 years. The disease often manifests as a painless mass in the testicles, sometimes accompanied by a sensation of heaviness or a dull ache.
Prostate disorders are another major concern. These conditions can impair urinary flow due to the prostate's location around the urethra....
3.9K
Parkinson's Disease: Treatment01:24

Parkinson's Disease: Treatment

867
Neurodegenerative disorders, such as Parkinson's Disease (PD), involve the gradual and irreversible destruction of neurons in particular brain areas. These disorders exhibit standard features like proteinopathies, selective vulnerability of some neurons, and an interaction of intrinsic properties, genetics, and environmental influences in neural injury.
Parkinson's Disease is primarily a result of the loss of dopaminergic neurons in the substantia nigra pars compacta. The cornerstone of...
867
Peripheral Artery Disease I: Introduction01:30

Peripheral Artery Disease I: Introduction

237
Peripheral artery disease (PAD) predominantly results from atherosclerosis, which involves the accumulation of fatty deposits, or plaques, within the walls of arteries. This causes them to narrow and harden, significantly reducing blood flow. PAD predominantly affects the legs, particularly the arteries supplying the thighs and calves. In rare cases, it may involve other arteries, including those in the arms.Etiology of PAD:The principal cause of PAD is atherosclerosis, which results from fatty...
237
Peripheral Artery Disease III: Interprofessional Care01:27

Peripheral Artery Disease III: Interprofessional Care

182
Peripheral Artery Disease (PAD) is characterized by narrowed arteries that diminish blood flow to the extremities. Effective management of PAD requires an interprofessional approach involving various healthcare professionals. The critical aspects of interprofessional care for PAD patients focus on risk factor modification, drug therapy, exercise therapy, nutrition therapy, critical limb ischemia care, and interventional radiology and surgical procedures.The primary treatment goal for PAD...
182
Parkinson's Disease: Overview01:15

Parkinson's Disease: Overview

1.6K
Neurodegenerative disorders are progressive diseases that cause irreversible damage and loss to neurons in specific brain areas. Examples of these disorders include Parkinson's disease, Alzheimer's disease, Multiple Sclerosis (MS), and Amyotrophic Lateral Sclerosis (ALS). These disorders share characteristics such as proteinopathies, selective neuronal vulnerability, and a complex interplay between genetic and environmental factors. The primary therapeutic goal for these conditions is...
1.6K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Contemporary Practices in the Assessment and Management of Climacturia: Results from an International Survey.

European urology open science·2026
Same author

Testosterone Therapy After Radical Prostatectomy: Insights From a Systematic Review and Meta-Analysis.

Andrology·2026
Same author

Priapism: how far have we come and the road ahead.

International journal of impotence research·2026
Same author

Single Epididymis Metastasis 12 Years After Radical Prostatectomy: A Case Report and Literature Review.

Case reports in urology·2026
Same author

A comparative evaluation of on-demand phosphodiesterase-5 inhibitor efficacy in erectile dysfunction treatment: a systematic review and network meta-analysis of double-blind, placebo-controlled, randomized trials.

The journal of sexual medicine·2026
Same author

Priapism: an overview and update.

International journal of impotence research·2026

Related Experiment Video

Updated: Dec 26, 2025

Microscopic Electric Rotary Grinding of Plaques Combined with Graft Repair in the Management of Peyronie's Disease
02:21

Microscopic Electric Rotary Grinding of Plaques Combined with Graft Repair in the Management of Peyronie's Disease

Published on: March 15, 2024

1.2K

[Peyronie's Disease: update in 2020].

Antoine Faix1,2, Daniel Chevallier1,3, Carlo Bettocchi1,4

  • 1MHISC (Men's Health International Surgical Center), 3, route du Muids, 1272 Genolier.

Revue Medicale Suisse
|March 19, 2020
PubMed
Summary

Peyronie's disease, a cause of sexual dysfunction, can lead to penile deformity and pain. While medical treatments offer some improvement, surgery is the primary option for stabilized conditions with significant sexual disability.

More Related Videos

Iatrogenic Injury Recapitulated: Electroexcision Technique for Urethral Stricture Modeling in Rats
03:37

Iatrogenic Injury Recapitulated: Electroexcision Technique for Urethral Stricture Modeling in Rats

Published on: October 11, 2024

650
Urethroplasty with Pedicled Tunica Vaginalis for the Treatment of Long-segment Anterior Urethral Stricture Caused by Lichen Sclerosus of Glans Penis
03:55

Urethroplasty with Pedicled Tunica Vaginalis for the Treatment of Long-segment Anterior Urethral Stricture Caused by Lichen Sclerosus of Glans Penis

Published on: October 18, 2024

607

Related Experiment Videos

Last Updated: Dec 26, 2025

Microscopic Electric Rotary Grinding of Plaques Combined with Graft Repair in the Management of Peyronie's Disease
02:21

Microscopic Electric Rotary Grinding of Plaques Combined with Graft Repair in the Management of Peyronie's Disease

Published on: March 15, 2024

1.2K
Iatrogenic Injury Recapitulated: Electroexcision Technique for Urethral Stricture Modeling in Rats
03:37

Iatrogenic Injury Recapitulated: Electroexcision Technique for Urethral Stricture Modeling in Rats

Published on: October 11, 2024

650
Urethroplasty with Pedicled Tunica Vaginalis for the Treatment of Long-segment Anterior Urethral Stricture Caused by Lichen Sclerosus of Glans Penis
03:55

Urethroplasty with Pedicled Tunica Vaginalis for the Treatment of Long-segment Anterior Urethral Stricture Caused by Lichen Sclerosus of Glans Penis

Published on: October 18, 2024

607

Area of Science:

  • Urology
  • Andrology
  • Sexual Medicine

Background:

  • Peyronie's disease is an often overlooked cause of sexual dysfunction.
  • It can manifest as penile deformity, pain, and erectile dysfunction (ED).
  • The exact cause of Peyronie's disease is frequently unknown.

Purpose of the Study:

  • To summarize the key aspects of Peyronie's disease.
  • To highlight the limitations of current medical treatments.
  • To underscore the role of surgical intervention in managing advanced cases.

Main Methods:

  • Review of existing literature on Peyronie's disease.
  • Analysis of symptom presentation and etiological factors.
  • Evaluation of treatment outcomes for medical and surgical interventions.

Main Results:

  • Peyronie's disease presents with penile curvature, pain, and ED.
  • Etiology remains largely unclear in most patients.
  • Medical therapies have limited efficacy, with variable improvement.
  • Surgical treatment is the definitive option for stable disease with significant disability.

Conclusions:

  • Peyronie's disease significantly impacts sexual function.
  • Limited effectiveness of non-surgical treatments necessitates surgical consideration.
  • Surgery offers a viable solution for patients with stabilized Peyronie's disease and severe sexual dysfunction.