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Heparanase Involvement in Exosome Formation.

Guido David1,2, Pascale Zimmermann3,4

  • 1Centre de Recherche en Cancérologie de Marseille (CRCM), Equipe labellisée LIGUE 2018, Aix-Marseille Université, Marseille F-13284, France and Inserm U1068, Institut Paoli-Calmettes, and CNRS UMR7258, Marseille, France.

Advances in Experimental Medicine and Biology
|April 11, 2020
PubMed
Summary

Syntenin and heparanase regulate exosome biogenesis, a process crucial for cell signaling. Their upregulation in cancers suggests exosomes play a role in tumor biology.

Keywords:
ALIXESCRTExosomal cargoHeparan sulfateHeparanasePDZ domainsSyndecanSynteninTumor progression

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