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Related Concept Videos

lncRNA - Long Non-coding RNAs02:39

lncRNA - Long Non-coding RNAs

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In humans, more than 80% of the genome gets transcribed. However, only around 2% of the genome codes for proteins. The remaining part produces non-coding RNAs which includes ribosomal RNAs, transfer RNAs, telomerase RNAs, and regulatory RNAs, among other types. A large number of regulatory non-coding RNAs have been classified into two groups depending upon their length – small non-coding RNAs, such as microRNA, which are less than 200 nucleotides in length, and long non-coding RNA...
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lncRNA - Long Non-coding RNAs02:39

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Types of RNA01:20

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Three main types of RNA are involved in protein synthesis: messenger RNA (mRNA), transfer RNA (tRNA), and ribosomal RNA (rRNA). These RNAs perform diverse functions and can be broadly classified as protein-coding or non-coding RNA. Non-coding RNAs play important roles in regulating gene expression in response to developmental and environmental changes. Non-coding RNAs in prokaryotes can be manipulated to develop more effective antibacterial drugs for human or animal use.
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Types of RNA01:23

Types of RNA

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Overview
Three main types of RNA are involved in protein synthesis: messenger RNA (mRNA), transfer RNA (tRNA), and ribosomal RNA (rRNA). These RNAs perform diverse functions and can be broadly classified as protein-coding or non-coding RNA. Non-coding RNAs play important roles in the regulation of gene expression in response to developmental and environmental changes. Non-coding RNAs in prokaryotes can be manipulated to develop more effective antibacterial drugs for human or animal use.
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RNA Stability01:53

RNA Stability

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Intact DNA strands can be found in fossils, while scientists sometimes struggle to keep RNA intact under laboratory conditions. The structural variations between RNA and DNA underlie the differences in their stability and longevity. Because DNA is double-stranded, it is inherently more stable. The single-stranded structure of RNA is less stable but also more flexible and can form weak internal bonds. Additionally, most RNAs in the cell are relatively short, while DNA can be up to 250 million...
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Nuclear Export of mRNA02:31

Nuclear Export of mRNA

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Before mRNAs are exported to the cytoplasm, it is crucial to check each mRNA for structural and functional integrity. Eukaryotic cells use several different mechanisms, collectively known as mRNA surveillance, to look for irregularities in mRNAs. Irregular or aberrant mRNA are rapidly degraded by various enzymes. If a defective mRNA escapes the surveillance, it would be translated into a protein which would either be non-functional or not function properly. One of the primary irregularities in...
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Related Experiment Video

Updated: Dec 24, 2025

In Vivo Nanovector Delivery of a Heart-specific MicroRNA-sponge
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Non-coding RNAs and Cardiac Aging.

Cuimei Zhao1, Guoping Li2, Jin Li3

  • 1Department of Cardiology, Shanghai Tongji Hospital, Tongji University School of Medicine, Shanghai, China.

Advances in Experimental Medicine and Biology
|April 15, 2020
PubMed
Summary
This summary is machine-generated.

Cardiac aging exacerbates cardiovascular disease risk and burden. Noncoding RNAs (ncRNAs) are key regulators of cardiac aging, offering potential therapeutic targets for age-related heart conditions.

Keywords:
Cardiac ageingCircular RNALong noncoding RNAmiRNA

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Area of Science:

  • Cardiology
  • Molecular Biology
  • Gerontology

Background:

  • Aging is a primary risk factor for cardiovascular diseases (CVDs), increasing patient morbidity and mortality.
  • The global aging population significantly elevates the medical burden of age-related cardiovascular diseases.
  • Understanding the mechanisms and treatments for cardiac aging is crucial.

Purpose of the Study:

  • To summarize the physiology and molecular mechanisms of cardiac aging.
  • To review recent research on noncoding RNAs (ncRNAs) in cardiac aging.
  • To explore ncRNAs as potential therapeutic targets for aging-related cardiovascular diseases.

Main Methods:

  • Literature review of cardiac aging.
  • Analysis of ncRNA involvement in cellular processes relevant to aging.
  • Synthesis of current research on ncRNAs and cardiac aging.

Main Results:

  • Noncoding RNAs (ncRNAs), including microRNAs, long noncoding RNAs, and circular RNAs, are implicated in cardiac aging.
  • ncRNAs regulate key cellular processes such as proliferation, differentiation, cell death, and hypertrophy in the heart.
  • Studies highlight the significant role of ncRNAs in the molecular landscape of cardiac aging.

Conclusions:

  • ncRNAs are critical regulators in the process of cardiac aging.
  • Further research into ncRNAs offers new insights into the regulatory mechanisms of cardiac aging.
  • ncRNAs represent promising therapeutic targets for treating aging-related cardiovascular diseases.