Related Experiment Video
Updated: Dec 7, 2025
10:19
A Murine Model of Group B Streptococcus Vaginal Colonization
Published on: November 16, 2016
14.8K
Group B Streptococcal Disease in England (1998 - 2017): A Population-based Observational Study
Seilesh Kadambari1, Caroline L Trotter2, Paul T Heath3
1Oxford Vaccine Group, Department of Paediatrics, University of Oxford, and the NIHR Oxford Biomedical Research Centre, Oxford, United Kingdom.
Summary
Group B Strep (GBS) disease incidence in infants remains stable, but GBS-attributable mortality has significantly decreased. Further prevention strategies, like maternal vaccination, are crucial for infant health.
Area of Science:
- Neonatal Medicine
- Infectious Diseases
- Public Health
Background:
- Group B Streptococcus (GBS) is a primary cause of sepsis and meningitis in neonates.
- Understanding the burden of GBS disease in infants is critical for public health initiatives.
Purpose of the Study:
- To assess the incidence and mortality of GBS disease in infants under 90 days in England.
- To compare GBS-affected infants with the general infant population regarding health outcomes and mortality.
Main Methods:
- Utilized linked National Health Service (NHS) hospitalization records from 1998 to 2017.
- Calculated annual GBS incidence and mortality rates.
- Employed regression models to compare outcomes between GBS-affected and unaffected infants.
Main Results:
- 15,429 infants diagnosed with GBS, with an average annual incidence of 1.28 per 1000 live births.
- GBS-attributable mortality significantly declined by an annual percentage change of -6.6% from 2001 to 2017.
- Infants with GBS exhibited higher relative rates of visual impairment, cerebral palsy, hydrocephalus, and necrotizing enterocolitis.
Conclusions:
- GBS disease incidence in infants has remained unchanged over 19 years.
- Reduced mortality is attributed to improved antibiotic use and neonatal care.
- Prioritizing new prevention methods, including maternal vaccination, is essential.
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