Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Whole Body Regeneration01:33

Whole Body Regeneration

3.6K
Regeneration is the process of restoring injured or lost tissues, organs, or body parts. While simpler organisms generally show greater ability to regenerate their whole body, few complex animals show similarly exceptional regeneration. For example, planarian flatworms have a unique regenerative potential making them a popular study organism among biologists to understand the mechanisms of whole body regeneration. Other organisms, such as hydra, also show extreme regeneration potential;...
3.6K
Overview of Regeneration and Repair01:19

Overview of Regeneration and Repair

4.4K
Regeneration and repair processes are critical in healing damages caused by injury, disease, and aging. In regeneration, the damaged tissue is entirely replaced with new growth that restores the original architecture and function. In contrast, tissue repair usually results in a fixed tissue architecture involving scar formation. Scars generally do not reestablish tissue function and may also exhibit structural abnormalities at the injury site.
Regeneration
All animals have varying degrees of...
4.4K
Genomic Imprinting and Inheritance02:30

Genomic Imprinting and Inheritance

35.5K
Diploid organisms inherit genetic material through chromosomes from both parents. Copies of the same gene are known as alleles. In most cases, both alleles are simultaneously expressed and allow various cellular processes to function optimally. If one of the alleles is missing or mutated, the expression of the other allele can compensate; however, this is not true for all genes.
The expression of some genes depends on which parent passed the gene to the offspring, through a phenomenon known as...
35.5K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

A cohort intervention to boost space health grant funding success for researchers from historically minoritized groups: 2022-2023.

NPJ microgravity·2026
Same author

Precision Biomaterials: Incorporating Sex, Age, and Social Descriptors in Biomaterials Research.

ACS biomaterials science & engineering·2026
Same author

Injectable aptamer-functionalized nucleic acid-collagen hydrogels as a bioactive platform for angiogenic applications.

Biomaterials advances·2025
Same author

Cell line-specific estrogen responses uncover functional sex differences in murine macrophages.

Biology of sex differences·2025
Same author

Modeling Uterine Fibroids Using Bioengineered Hydrogels.

ACS biomaterials science & engineering·2025
Same author

Toward Bioactive Hydrogels: A Tunable Approach via Nucleic Acid-Collagen Complexation.

Regenerative engineering and translational medicine·2025

Related Experiment Video

Updated: Oct 13, 2025

A Reverse Genetic Approach to Test Functional Redundancy During Embryogenesis
06:59

A Reverse Genetic Approach to Test Functional Redundancy During Embryogenesis

Published on: August 11, 2010

12.1K

Ancestral Background Is Underreported in Regenerative Engineering.

Holly Ryan1, Daniel Bister2, Sophia A Holliday2

  • 1J. Crayton Pruitt Family Department of Biomedical Engineering, University of Florida, Gainesville, FL 32611 USA.

Regenerative Engineering and Translational Medicine
|November 15, 2021
PubMed
Summary
This summary is machine-generated.

Most research fails to report human cell donor ancestry, hindering precision medicine. Increased reporting of ancestral background is crucial for developing personalized therapies and ensuring research applicability across diverse populations.

More Related Videos

Generation of Chimeric Axolotls with Mutant Haploid Limbs Through Embryonic Grafting
07:17

Generation of Chimeric Axolotls with Mutant Haploid Limbs Through Embryonic Grafting

Published on: January 29, 2020

7.4K
Rapid Genetic Analysis of Epithelial-Mesenchymal Signaling During Hair Regeneration
10:09

Rapid Genetic Analysis of Epithelial-Mesenchymal Signaling During Hair Regeneration

Published on: February 28, 2013

13.9K

Related Experiment Videos

Last Updated: Oct 13, 2025

A Reverse Genetic Approach to Test Functional Redundancy During Embryogenesis
06:59

A Reverse Genetic Approach to Test Functional Redundancy During Embryogenesis

Published on: August 11, 2010

12.1K
Generation of Chimeric Axolotls with Mutant Haploid Limbs Through Embryonic Grafting
07:17

Generation of Chimeric Axolotls with Mutant Haploid Limbs Through Embryonic Grafting

Published on: January 29, 2020

7.4K
Rapid Genetic Analysis of Epithelial-Mesenchymal Signaling During Hair Regeneration
10:09

Rapid Genetic Analysis of Epithelial-Mesenchymal Signaling During Hair Regeneration

Published on: February 28, 2013

13.9K

Area of Science:

  • Genetics and Genomics
  • Biomedical Research
  • Cell Biology

Background:

  • Human cell ancestry influences in vitro behavior and therapeutic responses.
  • Current biological research exhibits a significant deficit in reporting donor ancestral or ethnic information.
  • This lack of reporting impacts the generalizability of findings and the development of precision medicine.

Discussion:

  • A systematic review of ten journals over six months revealed minimal reporting on the ancestral origins of human cells.
  • The majority of studies using human primary cells and immortalized cell lines do not ascertain or report donor ancestry.
  • This oversight may lead to results that are not universally applicable to diverse patient populations.

Key Insights:

  • Overwhelmingly, scientific literature lacks data on the ancestral background of human cells used in research.
  • Ancestry is a critical, yet underreported, variable in experimental design.
  • Increased ancestral reporting is essential for advancing biomedical research and personalized medicine.

Outlook:

  • Promote widespread adoption of ancestry reporting in experimental design and publications.
  • Foster greater awareness within the research community regarding the importance of donor ancestry.
  • Future research should integrate ancestry as a standard variable to improve the precision and inclusivity of medical treatments.