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Skin Cancer

Skin Cancer

Skin cancer is a type of cancer that occurs when there is an abnormal growth of skin cells, usually triggered by damage to the DNA within the skin cells. It is primarily caused by exposure to ultraviolet (UV) radiation from the sun or artificial sources like tanning beds. Skin cancer is the most common type of cancer worldwide, and its incidence continues to rise.
Basal Cell Carcinoma (BCC): BCC is the most common type of skin cancer, accounting for about 80% of cases. It typically develops in...

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Dermatofibrosarcoma Protuberans: What Is This?

Gerardo A Vitiello¹, Ann Y Lee², Russell S Berman³

¹Department of Surgery, Division of Surgical Oncology, New York University Langone Health, 550 First Avenue, NBV 15 North-1, New York, NY 10016, USA. Electronic address: https://twitter.com/GerardoVitiello.

The Surgical Clinics of North America

|August 11, 2022

Summary

This summary is machine-generated.

Dermatofibrosarcoma protuberans (DFSP) is a rare skin sarcoma. Surgical removal is the primary cure, with targeted therapies showing promise for advanced cases.

Keywords:

DFSP Dermatofibrosarcoma protuberans Surgical considerations

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Area of Science:

Oncology
Dermatology
Surgical Pathology

Background:

Dermatofibrosarcoma protuberans (DFSP) is a rare, locally aggressive skin sarcoma.
It originates in the dermis and has a low metastatic potential, except when undergoing fibrosarcomatous transformation.
A characteristic t(17;22) translocation drives PDGFB signaling in DFSP.

Purpose of the Study:

To summarize the key characteristics, treatment modalities, and therapeutic outcomes for Dermatofibrosarcoma protuberans.
To highlight the importance of surgical resection and the role of targeted therapies and radiation.

Main Methods:

Review of existing literature on Dermatofibrosarcoma protuberans.
Analysis of treatment strategies including surgical resection, tyrosine kinase inhibitors, and radiation therapy.

Main Results:

Surgical resection with negative margins is the potentially curative treatment for DFSP.
Tyrosine kinase inhibitors (e.g., imatinib) demonstrate 50-60% response rates in advanced or metastatic DFSP.
Radiation therapy is effective for residual or recurrent DFSP.

Conclusions:

Complete surgical excision remains the cornerstone of curative treatment for DFSP.
Systemic therapies and radiation offer valuable options for managing advanced, unresectable, or recurrent disease.