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Published on: August 30, 2020
Biology and Hemodynamics of Aneurysm Rupture
Casey A Chitwood1, Elizabeth D Shih1, Omid Amili2
1Department of Biomedical Engineering, University of Minnesota Twin Cities, 312 Church St. SE, 7-105 Nils Hasselmo Hall, Minneapolis, MN 55455, USA.
Abstract:
Predicting rupture risk in intracranial aneurysms is among one of the most critical questions in vascular surgery. The processes that govern an aneurysm growth are multifaceted and complex, but may be summarized into three components: hemodynamics, biology, and mechanics. We review and connect the literature in the three disciplines, identifying considerable strides in recent history and current gaps in research. Taken together, the findings from each field elucidate how and why certain aneurysms rupture, whereas others remain stable. These parameters could eventually inform a translatable predictive model that optimizes risk evaluation and physician's decision-making in treatment options for aneurysms.
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