Renal handling of magnesium

In summary, magnesium reabsorption occurs throughout the proximal and distal segments of the nephron. The proximal tubule is less permeable to magnesium than calcium and sodium with most of the filtered load being reclaimed in the ascending loop of Henle. In contrast to calcium and sodium a tubular reabsorptive maximum has been demonstrated for magnesium and under certain circumstances secretion has been demonstrated in the terminal nephron segments. Although many factors are known to affect magnesium reabsorption the mechanism of the renal homeostasis remains to be determined.