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RADIATION-INDUCED DESTABILIZATION OF THE BLOOD LYMPHOCYTES' GENOME IN CANCER PATIENTS DEPENDING ON THEIR INDIVIDUAL RADIOSENSITIVITY.

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RELEVANT BIOCHEMICAL INDICES OF BLOOD RADIOSENSITIVITY IN GYNECOLOGICAL CANCER PATIENTS.

E A Domina1, L I Makovetska1, M O Druzhyna1

  • 1R. E. Kavetsky Institute of Experimental pathology, Oncology and Radiobiology of National Academy of Sciences of Ukraine, Kyiv, Ukraine, 45 Vasylkivska St., Kyiv, 03022, Ukraine.

Problemy Radiatsiinoi Medytsyny Ta Radiobiolohii
|December 30, 2022
PubMed
Summary

Malondialdehyde (MDA) in endometrial cancer patients

Keywords:
biochemical valuescancer patientsdose dependenceperipheral bloodradiation complicationsradiosensitivity

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Area of Science:

  • Biochemistry
  • Oncology
  • Radiation Oncology

Background:

  • Endometrial cancer patients exhibit elevated oxidative stress markers.
  • Understanding blood radiosensitivity is crucial for optimizing radiation therapy.
  • Biochemical indices may predict treatment response and complications.

Purpose of the Study:

  • To identify biochemical markers of blood radiosensitivity in endometrial cancer patients.
  • To investigate the dose-response relationship of these markers under test irradiation.
  • To establish malondialdehyde (MDA) as a prognostic indicator for radiation therapy.

Main Methods:

  • Assessed superoxide anion radical (O2) generation, pro/antioxidant ratio (PAR), and MDA in endometrial cancer patients and healthy donors.
  • Exposed blood samples to X-ray irradiation (0.5-3.0 Gy) to determine dose-response curves.
  • Utilized linear and linear-quadratic regression models to analyze biochemical parameter changes.

Main Results:

  • Endometrial cancer patients had 3.2 times higher MDA levels than controls.
  • MDA content increased linearly with radiation dose (0.5-3.0 Gy) in patients.
  • Increased O2 generation and PAR in patients indicated heightened prooxidant processes.

Conclusions:

  • Linear dose-dependence of MDA and its response to low-dose irradiation identify it as a prognostic indicator of radiosensitivity.
  • MDA levels in gynecological cancer patients are important for predicting radiation complications.
  • Interindividual variations in blood response to radiation highlight the need for personalized treatment planning.