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INTENSITY OF OXIDATIVE PROCESSES IN BLOOD AND LEVEL OF APOPTOSIS IN BLOOD LYMPHOCYTES IN RADIOLOGISTS/X-RAY TECHNOLOGIES EXPOSED TO SMALL DOSES OF IONIZING RADIATION.

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RELEVANT BIOCHEMICAL INDICES OF BLOOD RADIOSENSITIVITY IN GYNECOLOGICAL CANCER PATIENTS.

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CONTEMPORARY APPROACHES TO PROGNOSTICATION AND MANAGEMENT OF PELVIC RADIATION INJURIES IN GYNECOLOGICAL CANCER PATIENTS.

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PATHOGENESIS OF RADIATION COMPLICATIONS IN NORMAL TISSUES SURROUNDING AN IRRADIATED TUMOUR (review).

E A Domina1

  • 1R.E. Kavetsky Institute of Experimental Pathology, Oncology and Radiobiology, National Academy of Sciences of Ukraine, 45 Vasylkivska Str., Kyiv, 03022, Ukraine.

Problemy Radiatsiinoi Medytsyny Ta Radiobiolohii
|December 26, 2024
PubMed
Summary

New radiotherapy techniques can cause complications in healthy tissues. Predicting individual radiosensitivity with the chromosomal G2 test and developing targeted radioprotectors can mitigate these risks and improve patient quality of life.

Keywords:
cancer patientshealthy tissuesionizing radiationpathogenesispost-radiation complicationsradiation therapyradiobiological characteristicsradioprotection

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Area of Science:

  • Radiation Oncology
  • Radiobiology
  • Oncology

Background:

  • Modern radiotherapy, despite advancements, carries risks of early and distant complications in healthy tissues surrounding tumors.
  • Complication manifestation depends on tissue radiosensitivity and absorbed radiation dose; distant effects are irreversible and progressive.
  • Gynaecological oncology patients face increasing incidence and risk of critical pelvic organ complications.

Purpose of the Study:

  • To review the causes, pathogenesis, and radiobiological characteristics of radiation-induced complications.
  • To highlight the importance of predicting post-radiation complications in gynaecological oncology.
  • To advocate for the development of novel, non-toxic radioprotectors targeting healthy tissues.

Main Methods:

  • Review of existing literature on radiation technologies and complications.
  • Analysis of early radiation complication features in gynaecological oncology patients.
  • Focus on the chromosomal G2 test for predicting individual radiosensitivity.

Main Results:

  • Radiation complications are linked to absorbed dose and tissue radiosensitivity.
  • Distant radiation effects are irreversible and progressive.
  • The chromosomal G2 test shows potential for predicting individual radiosensitivity and post-radiation complications.

Conclusions:

  • Individual radiosensitivity assessment, using methods like the chromosomal G2 test, is crucial for predicting radiation complications.
  • Development of targeted, non-toxic radioprotectors is necessary to improve patient quality of life.
  • Further research into radioprotective strategies is essential for safer cancer radiotherapy.