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Cancer Survival Analysis01:21

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Cancer survival analysis focuses on quantifying and interpreting the time from a key starting point, such as diagnosis or the initiation of treatment, to a specific endpoint, such as remission or death. This analysis provides critical insights into treatment effectiveness and factors that influence patient outcomes, helping to shape clinical decisions and guide prognostic evaluations. A cornerstone of oncology research, survival analysis tackles the challenges of skewed, non-normally...
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RADIATION-INDUCED DESTABILIZATION OF THE BLOOD LYMPHOCYTES' GENOME IN CANCER PATIENTS DEPENDING ON THEIR INDIVIDUAL RADIOSENSITIVITY.

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Stereotactic Radiosurgery for Gynecologic Cancer
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CONTEMPORARY APPROACHES TO PROGNOSTICATION AND MANAGEMENT OF PELVIC RADIATION INJURIES IN GYNECOLOGICAL CANCER

V S Ivankova1, E A Domina2, T V Khrulenko1

  • 1National Cancer Institute, 33/43 Lomonosova st., Kyiv, 03022, Ukraine.

Problemy Radiatsiinoi Medytsyny Ta Radiobiolohii
|December 30, 2022
PubMed
Summary

High-energy brachytherapy (BT) using Iridium-192 sources improved gynecological cancer treatment outcomes compared to Cobalt-60. Transmembrane potential and reactive oxygen species in lymphocytes may predict radiation complications.

Keywords:
192Ir and 60Co high dose-rate sourcesHDR brachytherapy

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Area of Science:

  • Oncology
  • Radiation Medicine
  • Radiobiology

Background:

  • Advancements in radiation therapy (RT) and nanotechnologies aim to optimize dose delivery, minimizing healthy tissue irradiation.
  • Radiobiology principles are crucial for maintaining RT quality and improving treatment efficacy.

Purpose of the Study:

  • To compare high-dose-rate (HDR) brachytherapy (BT) using Iridium-192 (192Ir) versus Cobalt-60 (60Co) for gynecological cancer patients (GCPs).
  • To evaluate transmembrane potential (TMP) and reactive oxygen species (ROS) in peripheral blood lymphocytes (PBL) as radiosensitivity predictors for minimizing RT complications.

Main Methods:

  • 115 GCPs with stages II-III, T2-3N0-1M0 cancer received comprehensive conservative treatment with HDR BT and chemosensitizing agents.
  • Radiobiological analysis involved PBL samples from 24 GCPs and 18 apparently healthy individuals (AHIs).

Main Results:

  • HDR BT with 192Ir showed a 20.1% tumor response increase compared to 60Co (16.6%).
  • Grade II radiation reactions were infrequent in groups using 192Ir.
  • TMP levels in GCPs' PBL were 1.36 times higher than in AHIs.

Conclusions:

  • Treatment outcomes depend on planning accuracy, RT course reproduction, prophylaxis, tumor severity, and radiation source type (192Ir vs. 60Co).
  • Changes in TMP and ROS intensity in PBL can serve as indicators for predicting radiation complications before RT planning.