Optimal mechanical properties of Hydroxyapatite gradient Voronoi porous scaffolds for bone applications - A numerical...

Irregular Voronoi-based lattice (IVL) structures in tissue engineering (TE) have significant potential for bone regeneration. These scaffolds can mimic natural human bone interconnectivity by gradually altering strut thickness (ST) and seed point space (PS), which affects both mechanical and biological characteristics. This paper investigates the impact of design parameters, ST and PS, on Hydroxyapatite (HA) ILV structures' mechanical properties (elastic modulus (E) and maximum compressive strength (MCS)) and geometrical characteristics (pore number, size, and distribution, surface area (SA), and surface area-to-volume ratio (SA/VR)). Four types of IVL scaffolds were designed; PC-TC (Constant PS-Constant ST), PC-TG (Constant PS-Gradient ST), PG-TC (Gradient PS-Constant ST), and PG-TG (Gradient PS-Gradient ST). The study, conducted through linear static structural finite element analysis (FEA) with maximum stress criteria, underscores the profound impact of irregularity and morphology on mechanical performance and geometrical features. Regarding SA and SA/VR, a comparison between PC-TC with other proposed scaffolds showed a minor improvement for PC-TG, while higher significant improvements were found for both PG-TG and PG-TC. In terms of pores distribution and number, no noticeable improvement was observed for the PC-TG scaffold compared to PC-TC. In contrast, PG-TC and PG-TG lattices demonstrated a variety of pore distributions and approximately doubled pore numbers. Studying mechanical properties, considering E and MCS, showcases substantial gains for PG-TC. It, however, revealed that for the rest of the scaffolds, no enhancement was observed regarding E. Based on these results, gradient PS proved to be more effective than gradient ST in enhancing mechanical performance and geometrical properties. Due to these improvements, this study holds promise for expediting bone regeneration and reducing postoperative complications in bone replacement applications.