HEPCIDIN AND FERRITIN MODULATED IN OBESE MALE

Obesity has reached truly epidemic proportions worldwide and has become one of the most prevalent health problems that our world currently faces. The goal of the study is to identify the relationship between body mass index (BMI), insulin, hepcidin, and ferritin in obese males. Ninety males were recruited into the study; forty participants were assigned to the obese group were have BMI>30 kg/m2, twenty to overweight group were have BMI between 25-30 kg/m2, and another thirty to the control group were have slow BMI<25 kg/m2. The serum hepcidin, serum fasting insulin, serum ferritin and fasting glucose were evaluated in each of the studied groups. The Obese group showed a significant increase of the serum hepcidin concentration compared with the control group (4.65±1.92 vs. 3.43±1.52, p=0.015). No prominent differences were detected in the three groups in ferritin and glucose concentration. Investigation of iron regulated cytokine hepcidin can be participated in future as iron deficiency marker in obese subject in conjugation with serum iron and serum ferritin.