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EFFECT OF SURFACE TREATMENT PROTOCOLS OF ZIRCONIUM DIOXIDE MULTILAYER RESTORATIONS ON FUNCTIONAL PROPERTIES OF THE
O Mordanov1, Z Khabadze1, R Meremkulov1
1Medical Institute, Peoples' Friendship University of Russia named after Patrice Lumumba (RUDN), Russian Federation.
Georgian Medical News
|February 7, 2024
Summary
Surface treatments on zirconium dioxide dental restorations do not significantly affect oral stromal cells. Zirconia materials like Katana UTML and ZirCAD Prime showed no cytotoxicity, indicating their safety for oral mucosa applications.
Area of Science:
- Biomaterials Science
- Oral Biology
- Cell Biology
Background:
- Zirconium dioxide (zirconia) is widely used in dental restorations.
- Understanding the biocompatibility of different zirconia surface treatments is crucial for clinical success.
- Oral stromal cells play a vital role in tissue response to biomaterials.
Purpose of the Study:
- To investigate the impact of various surface treatment protocols on zirconium dioxide multilayer restorations.
- To evaluate the functional properties of human oral stromal cells when interacting with different zirconia materials.
- To assess the cytotoxicity and cellular response to novel zirconia formulations using molecular biological methods.
Main Methods:
- Standardized specimens of Katana (HTML, UTML, STML) and ZirCAD Prime zirconia were used.
- Human oral stromal cells were cultured and exposed to zirconia specimens in vitro.
- Cytotoxicity was assessed using the MTT assay, adhering to GOST R ISO 10993-5-2009 standards.
- Cellular occupancy and fibroblast prevalence on different surfaces were analyzed.
Main Results:
- ZirCAD Prime and Katana UTML groups exhibited no cytotoxic properties (cytotoxicity score "0").
- Katana STML samples showed minimal cytotoxicity (approx. 12% reduction), still considered non-cytotoxic.
- No statistically significant effect of different surface treatments on human oral stromal cells was observed.
- A higher prevalence of fibroblasts was noted on polished surfaces compared to glazed surfaces, though not statistically significant.
Conclusions:
- The tested surface treatment protocols for zirconium dioxide restorations generally demonstrate good biocompatibility with human oral stromal cells.
- Zirconia materials like ZirCAD Prime and Katana UTML are safe for intraoral use, showing no significant cytotoxicity.
- Further research may explore subtle differences in cellular response, particularly fibroblast behavior on varied surface finishes.
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