Related Experiment Video
Updated: Jun 28, 2025

09:01
Treatment of Ankle Osteoarthritis with Total Ankle Replacement Through a Lateral Transfibular Approach
Published on: January 24, 2018
11.8K
"Trend" Statement Use in the Orthopaedic Literature.
Andrew J Luzzi1, Natalia Czerwonka, Brandon Rogalski
1From the Department of Orthopedic Surgery, Columbia University Medical Center, New York, NY.
The Journal of the American Academy of Orthopaedic Surgeons
|April 10, 2024
Summary
"Trend statements" in orthopaedic research often describe non-statistically significant findings, potentially leading to misinterpretation. Researchers should define "trends" and avoid drawing undue conclusions from P-values greater than 0.10.
Area of Science:
- Orthopaedic Research
- Biostatistics
- Scientific Communication
Background:
- Accurate data interpretation is crucial for clinical decision-making.
- P-values are valuable but have limitations.
- "Trend statements" for non-significant findings introduce subjectivity and risk undue conclusions.
Purpose of the Study:
- To audit the use of "trend statements" in orthopaedic research.
- To analyze the frequency and context of these statements for non-statistically significant results.
Main Methods:
- Audit of original research articles from January 2022 to December 2022.
- Inclusion of four high-impact orthopaedic journals.
- Analysis of "trend statements" and associated P-values for non-significant findings.
Main Results:
- 81 out of 1260 articles (6.4%) used "trend statements" for non-significant results.
- Only 2.5% of studies defined what constituted a "trend".
- In 28.8% of cases, the P-value associated with the trend was > 0.10.
Conclusions:
- "Trend statements" are moderately frequent in orthopaedic literature for non-significant findings.
- Mitigation of "trend statement" use is recommended due to potential misleading effects.
- If used, "trends" must be defined, lack of statistical significance acknowledged, and undue conclusions avoided.
Related Concept Videos
Growth of Cartilage and Bone Tissue
3.2K
Chondrocytes form a temporary cartilaginous model by dividing and secreting a thick gel-like extracellular matrix. Once the chondrocytes undergo programmed cell death, osteoblasts enter the site of the cartilaginous model. The process of replacing the temporary cartilaginous model with bone in an ordered manner is called endochondral ossification. In endochondral ossification, not all of the cartilage is replaced by bone tissue. Some cartilage that performs a protective and supportive function...
3.2K
Osteoclasts in Bone Remodeling
2.9K
Osteoclasts are cells responsible for bone resorption and remodeling. They originate from hematopoietic progenitor cells present in the bone marrow. Numerous progenitor cells fuse to form multinucleated cells, each with 10-20 nuclei. A single osteoclast has a diameter of 150 to 200 µM. These cells have ruffled borders that break down the underlying bone tissue and release minerals such as calcium into the blood in bone resorption. Osteoclasts cling to bones with their ruffled edges during...
2.9K

