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Related Experiment Videos

Neonatal factor XIII deficiency.

J Landman, D Creter, R Homburg

    Clinical Pediatrics
    |June 1, 1985
    PubMed
    Summary
    This summary is machine-generated.

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    Persistent umbilical bleeding in newborns may indicate factor XIII deficiency, a rare bleeding disorder. Early screening for this condition is crucial when standard coagulation tests are normal.

    Area of Science:

    • Hematology
    • Pediatric Medicine
    • Coagulation Disorders

    Background:

    • Factor XIII deficiency is a rare inherited bleeding disorder.
    • It is the only coagulation factor deficiency undetectable by standard hemostatic tests.
    • Timely diagnosis is critical, especially within the first decade of life.

    Observation:

    • A neonate presented with persistent umbilical stump bleeding.
    • Routine coagulation tests performed on the patient were within normal limits.
    • This clinical presentation prompted further investigation into potential bleeding disorders.

    Findings:

    • The patient was diagnosed with factor XIII deficiency.
    • This diagnosis highlights the limitations of classical hemostatic tests in identifying factor XIII deficiency.

    Related Experiment Videos

  • The case underscores the importance of considering factor XIII deficiency in neonates with unexplained bleeding.

    • Implications:

    • Neonates with persistent umbilical bleeding and normal coagulation profiles require specific screening for factor XIII deficiency.
    • Early diagnosis and management of factor XIII deficiency can prevent severe complications.
    • This case contributes to the understanding of rare bleeding disorders in neonates and informs diagnostic protocols.