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Four vs. Six Implant Full-Arch Restorations-A Direct Comparative Retrospective Analysis in a Large Controlled
João Manuel Mendez Caramês1,2,3, Helena Cristina Oliveira Francisco1,2,3, Filipe Araújo Vieira1,2
1Instituto de Implantologia, Avenida Columbano Bordalo Pinheiro, No. 50, 1070-064 Lisbon, Portugal.
Journal of Clinical Medicine
|June 26, 2025
Summary
This study found that both four and six implants for implant-supported fixed complete dentures (IFCDs) show similar high implant survival rates. Patient-centered treatment planning and a systematic approach ensure comparable outcomes for dental implant longevity.
Area of Science:
- Oral and Maxillofacial Surgery
- Dental Implantology
- Prosthodontics
Background:
- The optimal number of implants (four vs. six) for implant-supported fixed complete dentures (IFCDs) remains debated regarding implant survival.
- This study addresses the inconclusive evidence by comparing implant survival rates between four and six implants in a large patient cohort.
Purpose of the Study:
- To compare the implant survival of immediately loaded IFCDs supported by four versus six implants.
- To evaluate the influence of treatment planning, patient factors, and anatomical considerations on implant survival.
Main Methods:
- Retrospective analysis of 943 patients and 5989 implants with a mean follow-up of 5.0 years.
- Utilized a systematic clinical decision support system (CDSS) based on alveolar atrophy classification (CC).
- Employed Kaplan-Meier analysis, log-rank tests, and multilevel Cox proportional hazard models to assess implant survival.
Main Results:
- Comparable 2- and 5-year cumulative survival rates (CSRs) for four vs. six IFCDs (2-year: 98.6% vs. 98.4%; 5-year: 98.8% vs. 98.7%).
- Implant loss was correlated with jaw type and age, but not significantly with alveolar atrophy (CC) within the CDSS.
- Differences between implant numbers were more pronounced at maxillary and mandibular levels but remained statistically non-significant.
Conclusions:
- Four and six IFCDs exhibit high and comparable mid-to-long-term implant survival rates when managed with a systematic, patient-centered CDSS.
- The number of implants (four vs. six) did not significantly impact implant survival in this cohort.
- Further research is needed to evaluate prosthetic and technical complications, which were outside the scope of this study.

