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Mandibular Defect Reconstruction Using Tissue Engineering: Case Report and Long-Term Follow-Up.

Rodrigo Fariña1,2, Jorge Lolas3, Emilio Moreno3

  • 1Service of Oral and Maxillofacial Surgery, Hospital del Salvador, Avenida Providencia 2330, Appt. 23., 75000 Providencia, Santiago, Chile.

Journal of Maxillofacial and Oral Surgery
|August 4, 2025
PubMed
Summary
This summary is machine-generated.

Tissue engineering using adipose-derived stem cells (ADSc) and beta-tricalcium phosphate (β-TCP) offers a predictable treatment for mandibular defects. This innovative approach successfully regenerated bone in a patient with ameloblastoma, enabling dental rehabilitation.

Keywords:
Adipose-derived stem cellsAmeloblastomaCase reportScaffoldsTissue engineeringβ-tricalcium phosphate

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Area of Science:

  • Regenerative Medicine
  • Oral and Maxillofacial Surgery
  • Biomaterials Science

Background:

  • Severe mandibular defects pose significant treatment challenges.
  • Tissue engineering presents a promising alternative with low morbidity.
  • Adipose-derived stem cells (ADSc) combined with ceramic scaffolds like β-TCP show potential for bone regeneration.

Observation:

  • A patient presented with a large plexiform unicystic ameloblastoma in the right mandibular body.
  • The tumor caused significant bone destruction and adjacent tooth root resorption.
  • Standard treatment involves surgical resection, often leading to functional and aesthetic deficits.

Findings:

  • ADSc were cultured with osteoinductive media and co-cultivated with β-TCP blocks.
  • A mandibular segmental resection was performed, and the ADSc/β-TCP composite was implanted on a titanium mesh.
  • Histological examination six months post-surgery confirmed successful bone neoformation at the defect site.

Implications:

  • This combined therapy demonstrates effective bone regeneration for severe mandibular defects.
  • The approach offers a good prognosis for treating benign neoplasms of the mandible.
  • Successful osseointegration of implants for dental rehabilitation is anticipated.