Related Experiment Video
Updated: Sep 10, 2025
09:06
Quantitative Analysis of Cellular Composition in Advanced Atherosclerotic Lesions of Smooth Muscle Cell Lineage-Tracing Mice
Published on: February 20, 2019
8.4K
Cardiovascular Aging: From Molecular Mechanisms to Targeted Therapies
Jenyfer María Fuentes-Mendoza1, Marcio José Concepción-Zavaleta2, Juan Muñoz-Moreno3
1Grupo de Investigación Neurociencias, Metabolismo, Efectividad Clínica y Sanitaria, Universidad Científica del Sur, Lima, Peru.
Molecular Diagnosis & Therapy
|August 26, 2025
Summary
This review explores how pharmacology, gene therapy, and regenerative medicine can combat cardiovascular aging. Advances in senolytics, metabolic regulators, and stem cells offer new hope for heart health in aging populations.
Area of Science:
- Cardiovascular Science
- Gerontology
- Regenerative Medicine
Background:
- Cardiovascular aging involves progressive cellular and molecular changes impacting heart and vascular function.
- Age-related cardiovascular decline presents a significant challenge to public health.
Purpose of the Study:
- To evaluate fundamental mechanisms and therapeutic strategies for mitigating age-related cardiovascular decline.
- To assess the clinical translation of recent advances in pharmacology, gene therapy, and regenerative medicine.
Main Methods:
- Comprehensive analysis of peer-reviewed studies (2000-2023) on cardiovascular aging mechanisms.
- Prioritization of clinical trials, translational research, and meta-analyses for therapeutic efficacy and safety assessment.
Main Results:
- Senolytic drugs (dasatinib, quercetin) reduce cardiovascular dysfunction; rapamycin and metformin improve cardiac longevity.
- Gene therapies (CRISPR), stem cell therapies, and nanotechnology show promise for cardiac regeneration and repair.
- Lifestyle interventions (Mediterranean diet, exercise) significantly improve vascular health in aging individuals.
Conclusions:
- Integrating targeted pharmacological treatments, regenerative techniques, and lifestyle interventions offers a transformative approach to managing cardiovascular aging.
- Challenges include drug delivery, patient-specific responses, and long-term safety of novel therapies.
- Future research should optimize therapeutic combinations, delivery methods, and biomarkers for clinical monitoring.
Related Concept Videos
01:26Aging
181
Aging is a complex biological phenomenon influenced by various processes that affect cellular and systemic functions. Several prominent theories attempt to explain its mechanisms, highlighting cellular limitations, oxidative damage, and hormonal changes as central factors in aging.
Cellular Clock Theory
The cellular clock theory posits that the human lifespan is closely tied to the finite capacity of cells to divide, a phenomenon governed by telomeres, which are protective caps at the ends of...
Cellular Clock Theory
The cellular clock theory posits that the human lifespan is closely tied to the finite capacity of cells to divide, a phenomenon governed by telomeres, which are protective caps at the ends of...
181
01:30Coronary Artery Disease I: Introduction
55
Coronary Artery Disease (CAD): An Overview with Scientific InsightsCoronary Artery Disease (CAD), often referred to as C-A-D, is a prevalent blood vessel disorder classified under the broader category of atherosclerosis. Atherosclerosis is a pathological process characterized by the hardening and narrowing of arteries due to the accumulation of atherosclerotic plaques. These plaques are composed of cholesterol, fatty substances, inflammatory cells, calcium, and fibrin, reducing blood flow to...
55
01:19The Effect of Aging on Tissues
2.4K
Several body functions deteriorate with age. The external signs of aging are easily identifiable. For example, the skin becomes dry, less elastic, and thins out, forming wrinkles. The skin of the face begins to appear looser due to a decrease in the levels of elastic and collagen fibers in the connective tissue. Additionally, melanin production in the hair follicle decreases with age, resulting in gray hair. Moreover, the senses of sight and hearing decline, so glasses and hearing aids may...
2.4K
01:26Atherosclerosis III: Management
33
Management of atherosclerosis involves an integrated strategy encompassing pharmacological treatment, surgical interventions, lifestyle changes, and nutrition therapy to address the multifactorial nature of the disease.Pharmacological TherapyA cornerstone of atherosclerosis management is the use of pharmacological agents. Statins, such as atorvastatin, are pivotal in inhibiting HMG-CoA reductase, an enzyme that catalyzes an initial step in cholesterol synthesis in the liver. This reduction in...
33
01:29Cardiomyopathy V: Interprofessional Care
33
Managing cardiomyopathy involves addressing underlying or precipitating causes, treating heart failure with medications, and implementing dietary changes and a balanced exercise and rest regimen.Lifestyle ModificationsCardiomyopathy patients should adopt a low-sodium diet to reduce fluid retention and manage heart failure. A personalized exercise and rest plan helps maintain physical fitness without overstraining the heart. Avoiding alcohol and tobacco is essential to prevent further damage to...
33
01:27Regulation of the Cardiovascular System
1.8K
The regulation of the cardiovascular system allows the body to adapt to various demands and maintain homeostasis.
The regulation of the cardiovascular system involves the autonomic nervous system (ANS), baroreceptors, and chemoreceptors, ensuring that heart rate and blood pressure are appropriately modulated in response to varying physiological demands.
The ANS comprises two main divisions: the sympathetic and parasympathetic nervous systems. The sympathetic nervous system enhances...
The regulation of the cardiovascular system involves the autonomic nervous system (ANS), baroreceptors, and chemoreceptors, ensuring that heart rate and blood pressure are appropriately modulated in response to varying physiological demands.
The ANS comprises two main divisions: the sympathetic and parasympathetic nervous systems. The sympathetic nervous system enhances...
1.8K