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Updated: Jan 31, 2026

Effects of Exposure of Formaldehyde to a Rat Model of Atopic Dermatitis Induced by Neonatal Capsaicin Treatment
Published on: September 27, 2017
Characterization of TNF-Alpha Inhibitor Induced Paradoxical Psoriasiform Dermatitis at a Single Center
Muayad M Shahin1, Emily S Gorell2, Mariam Iqneibi3
1University of Cincinnati College of Medicine, Cincinnati, Ohio, USA.
None:
Tumor necrosis factor-alpha inhibitors (TNFi) are used to treat various autoimmune diseases but can induce paradoxical psoriasiform dermatitis (PD) in a subset of patients. This retrospective chart review aimed to identify risk factors impacting PD severity in 70 pediatric patients at a single center. Forty patients (57.1%) discontinued their initial TNFi: 12/40 (30.0%) switched to another TNFi, with 4/12 (33.3%) experiencing PD recurrence, while 25/40 (62.5%) switched medication classes. Female sex was associated with increased use of high-potency topical steroids (p = 0.01), suggesting more severe disease. Juvenile idiopathic arthritis (p = 0.02), older age (p < 0.01), and concomitant immunomodulator use (p = 0.04) were associated with a longer latency period before PD development.
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