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Penetrating keratoplasty for herpes simplex keratitis
American Journal of Ophthalmology
|September 1, 1981
Summary
Penetrating keratoplasty success for herpes simplex keratitis is poor with active inflammation or ulceration. Conservative perforation management and quiet eyes offer better graft survival rates.
Area of Science:
- Ophthalmology
- Corneal Surgery
- Infectious Eye Diseases
Background:
- Herpes simplex keratitis (HSK) can lead to severe corneal damage requiring keratoplasty.
- HSK recurrence and inflammation often complicate corneal graft outcomes.
Purpose of the Study:
- To evaluate the outcomes of penetrating keratoplasty in patients with herpes simplex keratitis.
- To identify factors influencing graft success and develop a predictive model.
Main Methods:
- Retrospective longitudinal cohort study of 82 patients undergoing penetrating keratoplasty for HSK.
- Analysis of preoperative ocular status and management techniques.
- Development and testing of a predictive model for graft outcomes.
Main Results:
- Overall graft clarity was 39% (32/82 grafts).
- Poor outcomes were associated with active inflammation, ulceration, perforation, and extensive neovascularization.
- Conservative management of perforation (85% success) and quiet eyes showed good prognosis.
Conclusions:
- Penetrating keratoplasty for HSK has a guarded prognosis, especially with active disease.
- Preoperative factors significantly impact graft survival.
- A predictive model can aid in managing expectations and surgical planning for HSK keratoplasty.