[Interleukin-1 production by exudate and bone marrow macrophages in experimental acute infectious peritonitis]

The model of acute infectious peritonitis in mice has been used to show that inflammation is attended by a marked phasic increase in interleukin-1 (IL-1) production by macrophages of exudate and bone marrow. The increased IL-1 production by macrophages of exudate proceeds earlier than that by macrophages of the bone marrow. This indicates that activation of the bone marrow macrophages may be a result of the effect of OL-1 and other haemopoietic factors released by macrophages on the inflammatory focus.