Henriëtte Willems

8PUBLICATIONS
18CO-AUTHORS
Neurology and neuromuscular diseasesCheminformatics and quantitative structure-activity relationshipsClinical pharmacology and therapeuticsProteins and peptidesBiologically active molecules
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Publications (8)

|Nov 19, 2025
Development of Purine and Pyrrolopyrimidine Scaffolds as Potent, Selective, and Brain Penetrant NUAK1 Inhibitors.

Gregory G Aldred, Helen K Boffey, Henriette M G Willems

|Feb 19, 2025
Development of the Pyrido[2,3-d]pyrimidin-7(8H)-one Scaffold toward Potent and Selective NUAK1 Inhibitors.

Timothy P C Rooney, Gregory G Aldred, David Winpenny

|Oct 20, 2023
The rational design of ARUK2007145, a dual inhibitor of the α and γ isoforms of the lipid kinase phosphatidylinositol 5-phosphate 4-kinase (PI5P4K).

Gregory G Aldred, Timothy P C Rooney, Henriette M G Willems

|May 30, 2023
Identification of ARUK2002821 as an isoform-selective PI5P4Kα inhibitor.

Henriëtte M G Willems, Simon Edwards, Helen K Boffey

|Dec 14, 2022
The Identification of Potent, Selective, and Brain Penetrant PI5P4Kγ Inhibitors as In Vivo-Ready Tool Molecules.

Timothy P C Rooney, Gregory G Aldred, Helen K Boffey

|Oct 27, 2021
Fragment-Guided Discovery of Pyrazole Carboxylic Acid Inhibitors of the Kelch-like ECH-Associated Protein 1: Nuclear Factor Erythroid 2 Related Factor 2 (KEAP1:NRF2) Protein-Protein Interaction.

David Norton, William G Bonnette, James F Callahan

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Frequent Collaborators

5 joint publications

Stephen P Andrews

5 joint publications

Jonathan H Clarke

5 joint publications

John Skidmore

4 joint publications

Helen K Boffey