Related Experiment Videos
On the regulation of beta 2 integrins
M A Arnaout1, M Michishita, C P Sharma
1Leukocyte Biology and Inflammation Program, Massachusetts General Hospital, Boston.
Advances in Experimental Medicine and Biology
|January 1, 1992
Abstract:
The complex functions played by beta 2 integrins in mediating a large variety of adhesive interactions of leukocytes are highly regulated. This regulation results in transient adaptations/associations, permitting physical and functional recycling of these receptors during chemotaxis, phagocytosis and target-cell killing. The structural definition of these adaptations will lead not only to a better understanding of how these receptors are regulated in leukocytes but also shed valuable light on how these integrins integrate diverse extracellular signals into spatially and temporaly coordinated cellular responses.