Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Radiation physics for particle beam radiosurgery.

J T Lyman1, M H Phillips, K A Frankel

  • 1Division of Research Medicine and Radiation Biophysics, Lawrence Berkeley Laboratory, University of California, Berkeley.

Neurosurgery Clinics of North America
|January 1, 1992
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Improving the Quality of Care in Radiation Oncology using Artificial Intelligence.

Clinical oncology (Royal College of Radiologists (Great Britain))·2021
Same author

A feasibility study of spatiotemporally integrated radiotherapy using the LQ model.

Physics in medicine and biology·2018
Same author

HEAVY-PARTICLE IONIZATION (H, HE, LI, B, C, N, O, F, NE, AR) AND THE PROLIFERATIVE CAPACITY OF NEOPLASTIC CELLS IN VIVO. UCRL-11033.

UCRL [reports]. U.S. Atomic Energy Commission·2014
Same author

PRELIMINARY REPORT ON HISTOPATHOLOGICAL CHANGES IN BRAIN FOLLOWING HEAVY-PARTICLE IRRADIATION. UCRL-11033.

UCRL [reports]. U.S. Atomic Energy Commission·2014
Same author

USE OF THE BRAGG PEAK FOR BRAIN-TUMOR THERAPY. UCRL-11184.

UCRL [reports]. U.S. Atomic Energy Commission·2014
Same author

THE RELATIVE EFFICIENCY OF HIGH-LET RADIATIONS (BRAGG-PEAK LITHIUM IONS) ON NORMAL RABBIT SKIN, USING INTEGRAL DOSE AS A BASIS FOR COMPARISON. UCRL-11387.

UCRL [reports]. U.S. Atomic Energy Commission·2014
Same journal

Intramedullary Spinal Cord Tumors.

Neurosurgery clinics of North America·2026
Same journal

Spinal Cord Deformities Associated with Intramedullary Spinal Cord Tumors.

Neurosurgery clinics of North America·2026
Same journal

Radiation Therapy for Spinal Cord Tumors.

Neurosurgery clinics of North America·2026
Same journal

Treatment Strategies of Intramedullary Spinal Cord Tumors.

Neurosurgery clinics of North America·2026
Same journal

Vascular Lesions of the Spinal Cord: Arteriovenous and Cavernous Malformations.

Neurosurgery clinics of North America·2026
Same journal

Hemangioblastomas of the Spinal Cord.

Neurosurgery clinics of North America·2026
See all related articles

Helium and carbon ions offer superior dose distributions for radiosurgery compared to protons. Carbon ions may represent the optimal charged-particle beam for advanced cancer treatment.

Area of Science:

  • Medical Physics
  • Radiation Oncology
  • Particle Therapy

Background:

  • Charged particle beams, including protons, helium, carbon, and neon ions, are utilized in radiosurgery.
  • Understanding beam characteristics like Bragg peak, dose fall-off, and exit dose is crucial for treatment planning.

Purpose of the Study:

  • To compare the therapeutic parameters of different charged particle beams for radiosurgery.
  • To evaluate the impact of varying beam quality (Linear Energy Transfer - LET) and Relative Biological Effectiveness (RBE) on dose distributions.
  • To identify the optimal charged particle beam for radiosurgery applications.

Main Methods:

  • Analysis of Bragg peak height and width, distal fall-off, and exit dose for various charged particles.
  • Comparison of beam deflection and peak-plateau ratios.

Related Experiment Videos

  • Modeling of isodose distributions considering depth-dependent LET and RBE variations.

    • Main Results:

    • Helium ions show a higher peak-plateau ratio and more rapid dose fall-off than protons, with a modest exit dose.
    • Carbon and neon ions, along with helium, can achieve effective isodose distributions.
    • Calculations suggest carbon ions may offer the most optimal beam characteristics for radiosurgery.

    Conclusions:

    • Heavy charged-particle beams provide superior dose distributions compared to photon and electron beams.
    • These advanced beams have demonstrated clinical utility in treating various cancers and intracranial disorders.
    • Carbon ions show promise as an optimal choice for radiosurgery due to their favorable physical and biological properties.