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Identification of OTX1 and OTX2 As Two Possible Molecular Markers for Sinonasal Carcinomas and Olfactory Neuroblastomas
Published on: February 28, 2019
Sinonasal carcinomas: epidemiology, pathology, and management
Stephan K Haerle1, Patrick J Gullane, Ian J Witterick
1Department of Otolaryngology - Head and Neck Surgery, Toronto General Hospital, University Health Network, Toronto, Ontario, Canada.
Neurosurgery Clinics of North America
|November 24, 2012
Summary
Sinonasal carcinomas are rare upper respiratory tract cancers often diagnosed late. Treatment involves surgery and radiation, with multidisciplinary approaches improving survival.
Area of Science:
- Oncology
- Otorhinolaryngology
Background:
- Sinonasal carcinomas represent 3-5% of upper respiratory tract malignancies.
- These cancers often present with advanced disease due to a lack of early symptoms.
Purpose of the Study:
- To outline the diagnostic and treatment strategies for sinonasal carcinomas.
- To highlight advancements in managing these rare neoplasms.
Main Methods:
- Diagnosis involves clinical and endoscopic examination, biopsy, and imaging.
- Treatment primarily includes surgical resection (open or endoscopic).
- Adjuvant or neoadjuvant radiation therapy is considered for advanced cases.
Main Results:
- Sinonasal carcinomas are generally radiosensitive.
- Multidisciplinary approaches combining surgery, radiation, ablation, and reconstruction have improved outcomes.
Conclusions:
- Early diagnosis is challenging, necessitating thorough staging.
- Integrated treatment strategies significantly enhance survival for sinonasal carcinoma patients.
