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Updated: May 15, 2026

Establishment of a Murine Pulp Exposure Model with a Novel Mouth-Gag for Pulpitis Research
Published on: October 27, 2023
[Structural features of the pulp ground substance and its significance for acute and chronic pulpitis]
Capital Ka Cyrillich Davarashvili1, M Dgebuadze, E Melikadze
1Dental Clinic N1, Kutaisi; Iv. Javakhishvili Tbilisi State University, A.N. Natishvili Institute of Morphology, Tbilisi, Georgia.
Abstract:
The goal of the research study is an analysis of amorphous material, fibers and cellular elements of the dental pulp and evaluation of their interactions with a variety of fibrouse structures in the norm and inflammation. To solve this problem used dental pulp tissue bioptats (10 cases) of patients with acute and chronic pulpitis and 10 control specimens (orthodontic operations). The material was studied by histological and electron microscopic methods of research. It was determined that in acute pulpitis develope changes promoting dissociation of fibrouse and cellular structures of pulp components, and thus, loss the cementing binding role of the ground substance. Acute pulpitis characterized by the recruitment of mast cells. ; The reorganization and remodeling of ground substance associated with neoangiogenesis, especially capillaries, and the replacement of collagen fibers by the fibrouse structures are major points in chronic pulpitis.
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